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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2010-2-23
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pubmed:abstractText |
In preclinical models, VEGF is a potent stimulant of both physiologic and pathologic angiogenesis. Conversely, anti-VEGF regimens have successfully inhibited angiogenesis both in vitro and in vivo. We hypothesized that VEGF would stimulate both physiologic and pathologic angiogenesis in a human-based fibrin-thrombin clot angiogenesis assay. We further speculated that anti-VEGF regimens would inhibit angiogenesis in this assay.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1095-8673
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pubmed:author |
pubmed-author:AnthonyCatherine TCT,
pubmed-author:BoudreauxJ PhilipJP,
pubmed-author:CaseyDouglas TDT,
pubmed-author:CundiffJason DJD,
pubmed-author:KuceraPaulP,
pubmed-author:LyonsJohn MJM3rd,
pubmed-author:MacciniCynthiaC,
pubmed-author:SchwimerJoshua EJE,
pubmed-author:ThomsonJessica LJL,
pubmed-author:WangYi-ZarnYZ,
pubmed-author:WolteringEugene AEA
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pubmed:copyrightInfo |
Copyright (c) 2010 Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
159
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
517-27
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pubmed:meshHeading |
pubmed-meshheading:19577260-Cells, Cultured,
pubmed-meshheading:19577260-Endothelial Cells,
pubmed-meshheading:19577260-Fibrin,
pubmed-meshheading:19577260-Humans,
pubmed-meshheading:19577260-Neovascularization, Pathologic,
pubmed-meshheading:19577260-Neovascularization, Physiologic,
pubmed-meshheading:19577260-Signal Transduction,
pubmed-meshheading:19577260-Thrombin,
pubmed-meshheading:19577260-Vascular Endothelial Growth Factor A
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pubmed:year |
2010
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pubmed:articleTitle |
The role of VEGF pathways in human physiologic and pathologic angiogenesis.
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pubmed:affiliation |
Louisiana State University Health Sciences Center Department of Surgery, Section of Surgical Oncology and Section of Surgical Endocrinology, Kenner, Louisiana 70065, USA.
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pubmed:publicationType |
Journal Article,
In Vitro
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