rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2010-2-17
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pubmed:abstractText |
Remodeling after myocardial infarction (MI) associates with left ventricular (LV) dilation, decreased cardiac function and increased mortality. The dynamic synthesis and breakdown of extracellular matrix (ECM) proteins play a significant role in myocardial remodeling post-MI. Expression of osteopontin (OPN) increases in the heart post-MI. Evidence has been provided that lack of OPN induces LV dilation which associates with decreased collagen synthesis and deposition. Inhibition of matrix metalloproteinases, key players in ECM remodeling process post-MI, increased ECM deposition (fibrosis) and improved LV function in mice lacking OPN after MI. This review summarizes--1) signaling pathways leading to increased expression of OPN in the heart; 2) the alterations in the structure and function of the heart post-MI in mice lacking OPN; and 3) mechanisms involved in OPN-mediated ECM remodeling post-MI.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19573532-10024324,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19573532-11375279,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19573532-11375993,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19573532-11382929,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19573532-11461752,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19573532-11959041,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19573532-12555139,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19573532-12775562,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19573532-12939547,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19573532-12952018,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19573532-14500723,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19573532-14563350,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19573532-14638549,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19573532-14751663,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19573532-14755545,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19573532-15120833,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19573532-15123578,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19573532-15364610,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19573532-15534078,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19573532-15668659,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19573532-16087132,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19573532-16183043,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19573532-16443044,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19573532-16980342,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19573532-17034340,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19573532-17127294,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19573532-17454675,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19573532-17717292,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19573532-17910028,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19573532-17928585,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19573532-18079410,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19573532-18276921,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19573532-18466418,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19573532-18471960,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19573532-18952487,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19573532-18979185,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19573532-19080183,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19573532-19246678,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19573532-2364493,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19573532-7499354,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19573532-7532190,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19573532-7641347,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19573532-7785895,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19573532-7992848,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19573532-8293561,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19573532-8941637,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19573532-9343813,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19573532-9386176,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19573532-9679721,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19573532-9880554
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1095-8584
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pubmed:author |
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pubmed:copyrightInfo |
Published by Elsevier Ltd.
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pubmed:issnType |
Electronic
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pubmed:volume |
48
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
538-43
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
|
pubmed:year |
2010
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pubmed:articleTitle |
Osteopontin: role in extracellular matrix deposition and myocardial remodeling post-MI.
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pubmed:affiliation |
Department of Physiology, James H Quillen College of Medicine, James H Quillen Veterans Affairs Medical Center, East Tennessee State University, PO Box 70576, Johnson City, TN 37614, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Review,
Research Support, N.I.H., Extramural
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