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rdf:type |
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lifeskim:mentions |
umls-concept:C0003873,
umls-concept:C0009498,
umls-concept:C0030705,
umls-concept:C0439858,
umls-concept:C0443177,
umls-concept:C1138802,
umls-concept:C1515877,
umls-concept:C1523987,
umls-concept:C1704259,
umls-concept:C1705987,
umls-concept:C1879547
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pubmed:issue |
7
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pubmed:dateCreated |
2009-7-14
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pubmed:abstractText |
It has been suggested that anti-citrullinated protein antibodies (ACPAs) play an important role in the pathogenesis of rheumatoid arthritis (RA). To exert their pathologic effects, ACPAs must recruit immune effector mechanisms such as activation of the complement system. Mouse models of RA have shown that, surprisingly, arthritogenic antibodies activate the alternative pathway of complement rather than the expected classical pathway. This study was undertaken to investigate whether human anti-cyclic citrullinated peptide (anti-CCP) antibodies activate the complement system in vitro and, if so, which pathways of complement activation are used.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Anti-Idiotypic,
http://linkedlifedata.com/resource/pubmed/chemical/Complement C1q,
http://linkedlifedata.com/resource/pubmed/chemical/Complement C5a,
http://linkedlifedata.com/resource/pubmed/chemical/Complement Membrane Attack Complex,
http://linkedlifedata.com/resource/pubmed/chemical/Complement System Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Lectins,
http://linkedlifedata.com/resource/pubmed/chemical/Mannose-Binding Lectin,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides, Cyclic,
http://linkedlifedata.com/resource/pubmed/chemical/cyclic citrullinated peptide
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0004-3591
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
60
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1923-31
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pubmed:meshHeading |
pubmed-meshheading:19565507-Adolescent,
pubmed-meshheading:19565507-Adult,
pubmed-meshheading:19565507-Aged,
pubmed-meshheading:19565507-Aged, 80 and over,
pubmed-meshheading:19565507-Antibodies, Anti-Idiotypic,
pubmed-meshheading:19565507-Arthritis, Rheumatoid,
pubmed-meshheading:19565507-Case-Control Studies,
pubmed-meshheading:19565507-Cohort Studies,
pubmed-meshheading:19565507-Complement C1q,
pubmed-meshheading:19565507-Complement C5a,
pubmed-meshheading:19565507-Complement Membrane Attack Complex,
pubmed-meshheading:19565507-Complement System Proteins,
pubmed-meshheading:19565507-Female,
pubmed-meshheading:19565507-Humans,
pubmed-meshheading:19565507-Lectins,
pubmed-meshheading:19565507-Male,
pubmed-meshheading:19565507-Mannose-Binding Lectin,
pubmed-meshheading:19565507-Middle Aged,
pubmed-meshheading:19565507-Peptides, Cyclic,
pubmed-meshheading:19565507-Signal Transduction,
pubmed-meshheading:19565507-Young Adult
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pubmed:year |
2009
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pubmed:articleTitle |
Anti-cyclic citrullinated peptide antibodies from rheumatoid arthritis patients activate complement via both the classical and alternative pathways.
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pubmed:affiliation |
Leiden University Medical Center, Leiden, The Netherlands. L.A.Trouw@lumc.nl
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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