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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2009-7-8
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pubmed:abstractText |
The evasion of host immune response by the human malaria parasite Plasmodium falciparum has been linked to expression of a range of variable antigens on the infected erythrocyte surface. Several genes are potentially involved in this process with the var, rif and stevor multigene families being the most likely candidates and coding for rapidly evolving proteins. The high sequence diversity of proteins encoded by these gene families may have evolved as an immune evasion strategy that enables the parasite to establish long lasting chronic infections. Previous findings have shown that the hypervariable region (HVR) of STEVOR has significant sequence diversity both within as well as across different P. falciparum lines. However, these studies did not address whether or not there are ancestral stevor that can be found in different parasites.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1475-2875
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
140
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:19558642-Animals,
pubmed-meshheading:19558642-Antigens, Protozoan,
pubmed-meshheading:19558642-Cluster Analysis,
pubmed-meshheading:19558642-DNA, Protozoan,
pubmed-meshheading:19558642-Evolution, Molecular,
pubmed-meshheading:19558642-Humans,
pubmed-meshheading:19558642-Kenya,
pubmed-meshheading:19558642-Malaria, Falciparum,
pubmed-meshheading:19558642-Multigene Family,
pubmed-meshheading:19558642-Phylogeny,
pubmed-meshheading:19558642-Plasmodium falciparum,
pubmed-meshheading:19558642-Polymorphism, Genetic,
pubmed-meshheading:19558642-RNA, Protozoan,
pubmed-meshheading:19558642-Selection, Genetic,
pubmed-meshheading:19558642-Sequence Analysis, DNA,
pubmed-meshheading:19558642-Sequence Homology
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pubmed:year |
2009
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pubmed:articleTitle |
Characterization of the repertoire diversity of the Plasmodium falciparum stevor multigene family in laboratory and field isolates.
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pubmed:affiliation |
Nanyang Technological University, School of Biological Sciences, Singapore, Singapore. JEB@kcs.org.uk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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