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rdf:type |
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lifeskim:mentions |
umls-concept:C0007634,
umls-concept:C0010656,
umls-concept:C0017638,
umls-concept:C0162638,
umls-concept:C0205263,
umls-concept:C1415288,
umls-concept:C1514485,
umls-concept:C1704970,
umls-concept:C1710082,
umls-concept:C1711351,
umls-concept:C1879547
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pubmed:issue |
1
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pubmed:dateCreated |
2009-7-7
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pubmed:abstractText |
Glioblastoma multiforme (GBM) is the most invasive and undifferentiated type of brain tumour, and so surgical interventions are ineffective. We found that GluR2 is absent in fast-growing GBM-derived tumour stem cells and high-grade glioma specimens, but is expressed in slow-growing stem cells and low-grade glioma specimens. More remarkably, GluR2 overexpression in U-87MG cells inhibits proliferation by inactivating extracellular signal-regulated kinase (ERK)1/2-Src phosphorylation and induces apoptosis. Mechanistically, we observed that the scaffold protein GRIP is essential for the effect of GluR2 on ERK-Src inactivation. These findings indicate that the absence of the GluR2 subunit favours malignancy.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CASP3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CASP6 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Casp3 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Casp6 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Caspase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Caspase 6,
http://linkedlifedata.com/resource/pubmed/chemical/GRIP1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Grip1 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, AMPA,
http://linkedlifedata.com/resource/pubmed/chemical/glutamate receptor ionotropic...,
http://linkedlifedata.com/resource/pubmed/chemical/src-Family Kinases
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1460-9568
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
30
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
25-34
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:19558602-Animals,
pubmed-meshheading:19558602-Apoptosis,
pubmed-meshheading:19558602-Carrier Proteins,
pubmed-meshheading:19558602-Caspase 3,
pubmed-meshheading:19558602-Caspase 6,
pubmed-meshheading:19558602-Cell Line, Tumor,
pubmed-meshheading:19558602-Cell Proliferation,
pubmed-meshheading:19558602-Glioma,
pubmed-meshheading:19558602-Humans,
pubmed-meshheading:19558602-MAP Kinase Signaling System,
pubmed-meshheading:19558602-Mitogen-Activated Protein Kinase 1,
pubmed-meshheading:19558602-Mitogen-Activated Protein Kinase 3,
pubmed-meshheading:19558602-Nerve Tissue Proteins,
pubmed-meshheading:19558602-Rats,
pubmed-meshheading:19558602-Receptors, AMPA,
pubmed-meshheading:19558602-src-Family Kinases
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pubmed:year |
2009
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pubmed:articleTitle |
The GluR2 subunit inhibits proliferation by inactivating Src-MAPK signalling and induces apoptosis by means of caspase 3/6-dependent activation in glioma cells.
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pubmed:affiliation |
DTI Dulbecco Telethon Institute, Via Vanvitelli 32, Milan 20129, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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