Linked Life Data

19558341

Source:http://linkedlifedata.com/resource/pubmed/id/19558341

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2009-7-15
pubmed:abstractText
Emedastine difumarate, a selective histamine-H1 receptor antagonist and effective antiallergic agent, inhibits various clinical symptoms of allergic rhinitis, allergic conjunctivitis, urticaria, allergic dermatitis, pruritus cutaneous, and prurigo. In addition to greater efficacy than other antihistamines, emedastine difumarate produces no adverse cardiovascular effects and exhibits minimal anticholinergic activity. Moreover, a recent study revealed that the effect of emedastine difumarate on inhibition of histamine-induced collagen synthesis in vitro was greater in dermal fibroblasts than in nasal mucosa fibroblasts. This result indicates that there are tissue-specific effects of emedastine difumarate and that it may be more effective for treating fibrosis in skin than in nasal mucosa. However, the mechanism and role of tissue remodeling is less well established for allergic skin diseases and allergic conjunctivitis, in comparison to respiratory allergic diseases.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1744-7666
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1859-67
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Emedastine difumarate: a review of its potential ameliorating effect for tissue remodeling in allergic diseases.
pubmed:affiliation
Osaka University, Graduate School of Medicine, Course of Integrated Medicine, Dermatology Department, 2-2 Yamadaoka, Suita-city, Osaka 5650871, Japan. h-murota@derma.med.osaka-u.ac.jp
pubmed:publicationType
Journal Article, Review