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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2009-6-26
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pubmed:abstractText |
Tbx1 is a T-box transcription factor implicated in DiGeorge syndrome. The molecular function of Tbx1 is unclear although it can transactivate reporters with T-box binding elements. We discovered that Tbx1 binds Smad1 and suppresses the Bmp4/Smad1 signaling. Tbx1 interferes with Smad1 to Smad4 binding, and a mutation of Tbx1 that abolishes transactivation, does not affect Smad1 binding nor does affect the ability to suppress Smad1 activity. In addition, a disease-associated mutation of TBX1 that does not prevent transactivation, prevents the TBX1-SMAD1 interaction. Expression of Tbx1 in transgenic mice generates phenotypes similar to those associated with loss of a Bmp receptor. One phenotype could be rescued by transgenic Smad1 expression. Our data indicate that Tbx1 interferes with Bmp/Smad1 signaling and provide strong evidence that a T-box transcription factor has functions unrelated to transactivation.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19557177-10077612,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19557177-10504710,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19557177-12223416,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19557177-14585638,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19557177-14623825,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19557177-15073157,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19557177-15175244,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19557177-15459107,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19557177-15469978,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19557177-15695370,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19557177-15699019,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19557177-15716346,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19557177-15736267,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19557177-15809041,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19557177-16169630,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19557177-16258075,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19557177-16285859,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19557177-16304598,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19557177-16322555,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19557177-16399080,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19557177-16556915,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19557177-16684884,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19557177-16720879,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19557177-16914493,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19557177-17047027,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19557177-17074316,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19557177-17205194,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19557177-17273972,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19557177-17350578,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19557177-18328475,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19557177-18981476,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19557177-19247433,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19557177-7797528,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19557177-9335504
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1932-6203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e6049
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:19557177-Animals,
pubmed-meshheading:19557177-Bone Morphogenetic Proteins,
pubmed-meshheading:19557177-COS Cells,
pubmed-meshheading:19557177-Cercopithecus aethiops,
pubmed-meshheading:19557177-Gene Expression Regulation,
pubmed-meshheading:19557177-Mice,
pubmed-meshheading:19557177-Mice, Inbred C57BL,
pubmed-meshheading:19557177-Mice, Transgenic,
pubmed-meshheading:19557177-Protein Structure, Tertiary,
pubmed-meshheading:19557177-Signal Transduction,
pubmed-meshheading:19557177-Smad1 Protein,
pubmed-meshheading:19557177-Smad4 Protein,
pubmed-meshheading:19557177-T-Box Domain Proteins,
pubmed-meshheading:19557177-Transcription, Genetic,
pubmed-meshheading:19557177-Transcriptional Activation
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pubmed:year |
2009
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pubmed:articleTitle |
Tbx1 regulates the BMP-Smad1 pathway in a transcription independent manner.
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pubmed:affiliation |
Telethon Institute of Genetics and Medicine, Naples, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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