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rdf:type |
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lifeskim:mentions |
|
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pubmed:issue |
10
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pubmed:dateCreated |
1991-12-27
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pubmed:abstractText |
Three prodrug esters (2a approximately 2c) of 3-(2-propenyl)cephem (1a) have been prepared and their oral absorption was determined in rats and mice. While pivaloyloxymethyl ester (2a) did not improve the oral absorption of the parent cephem 1a, [(1-methyl)ethoxycarbonyloxy]ethyl ester (2b) and (5-methyl-2-oxo-1,3-dioxolen-4-yl)methyl ester (2c) improved oral absorption by a factor of five.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0021-8820
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
44
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1083-7
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:1955390-Absorption,
pubmed-meshheading:1955390-Administration, Oral,
pubmed-meshheading:1955390-Animals,
pubmed-meshheading:1955390-Biological Availability,
pubmed-meshheading:1955390-Cephalosporins,
pubmed-meshheading:1955390-Kinetics,
pubmed-meshheading:1955390-Magnetic Resonance Spectroscopy,
pubmed-meshheading:1955390-Mice,
pubmed-meshheading:1955390-Prodrugs,
pubmed-meshheading:1955390-Rats,
pubmed-meshheading:1955390-Thiazoles
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|
pubmed:year |
1991
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|
pubmed:articleTitle |
Synthesis and biological activity of novel 3-(2-propenyl)-cephalosporins. II. Preparation of prodrugs.
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pubmed:affiliation |
Korea Research Institute of Chemical Technology, Daedeog-Danji, Daejeon.
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pubmed:publicationType |
Journal Article
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