Linked Life Data

19552464

Source:http://linkedlifedata.com/resource/pubmed/id/19552464

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
13
pubmed:dateCreated
2009-6-25
pubmed:abstractText
The synthesis and biological evaluation of structurally simplified, metabolically stable cyclopamine-like Sonic Hedgehog (SHH) signaling inhibitors, i.e., 5, is described in four chemical steps from commercially available steroidal precursors. Biological evaluation of this cyclopamine analogue in two different systems establishes the high potency of 5 as a SHH signaling inhibitor. This approach provides important new lead structures for the development of new cancer chemotherapeutic agents based on the inhibition on SHH signaling.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1523-7052
pubmed:author
pubmed:issnType
Electronic
pubmed:day
2
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2824-7
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Design and synthesis of inhibitors of Hedgehog signaling based on the alkaloid cyclopamine.
pubmed:affiliation
Department of Chemistry, The University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. winkler@sas.upenn.edu
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't