Linked Life Data

19538280

Source:http://linkedlifedata.com/resource/pubmed/id/19538280

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2009-6-22
pubmed:abstractText
Tight junctions of epithelial and endothelial cells form selective barriers that regulate paracellular transport of solutes, immune cells, and drugs. Tight junctions consist of proteins that physically "seal" the tight junction but also form channels that allow for permeation between the cells, resulting in epithelial surfaces of different tightness. The tight junction proteins occludin, tricellulin, and at least 24 members of the claudin family are characterized by four transmembranal domains and two extracellular loops that, like teeth of a zipper, contact the appropriate loops from opposing cell membranes. Tight junctions are regulated in their molecular composition, ultrastructure, and function by intracellular scaffolding proteins and the cytoskeleton; such regulation serves normal, physiologic adaptation but also occurs in numerous diseases.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1749-6632
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
1165
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1-6
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Tight junctions: molecular structure meets function.
pubmed:affiliation
Department of General Medicine, Campus Benjamin Franklin, Freie Universität and Humboldt-Universität, Berlin, Germany.
pubmed:publicationType
Introductory Journal Article