Linked Life Data

19538003

Source:http://linkedlifedata.com/resource/pubmed/id/19538003

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2009-6-22
pubmed:abstractText
Previous studies in vitro had identified niaouli essential oil (NEO) as a valuable transdermal permeation promoter for estradiol (ES). Subsequent considerations on the complex issue of NEO provenance and composition stimulated the present investigation, which was aimed at defining the composition of NEOs obtained from four different sources, at evaluating their influence on transdermal permeation of ES through hairless mouse skin, and at formulating and evaluating simpler terpene mixtures mimicking the NEOs' composition. While all oils contained 1,8-cineol (eucalyptol) as the main component, appreciable variations in composition could be evidenced, originating differences on the ES cutaneous permeation. Two artificial mixtures containing the same proportions of the main terpenes present in each oil (except the commercially unavailable gamma-terpineol) proved equal or significantly superior in activity when compared with the original oils. It is felt that this study might contribute to the formulation of terpene mixtures acting more efficiently and reproducibly with respect to natural NEOs, whose complex and variable composition, depending on growing place, season, and extraction process, is well documented in the relevant literature.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1521-0464
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
237-42
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Niaouli oils from different sources: analysis and influence on cutaneous permeation of estradiol in vitro.
pubmed:affiliation
Department of Pharmaceutical Sciences, University of Pisa, Pisa, Italy. montid@farm.unipi.it
pubmed:publicationType
Journal Article