| pubmed-article:19536153 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19536153 | lifeskim:mentions | umls-concept:C0085424 | lld:lifeskim |
| pubmed-article:19536153 | lifeskim:mentions | umls-concept:C0035245 | lld:lifeskim |
| pubmed-article:19536153 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:19536153 | lifeskim:mentions | umls-concept:C1882417 | lld:lifeskim |
| pubmed-article:19536153 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:19536153 | pubmed:dateCreated | 2009-9-2 | lld:pubmed |
| pubmed-article:19536153 | pubmed:abstractText | Sex differences in asthma-associated phenotypes are well known but the genetic factors that may account for these differences have received little attention. This study aimed to characterize sex-specific and pleiotropic genetic factors underlying four quantitative phenotypes involved in the main asthma physiopathological pathways: immunoglobulin E levels, a measure of polysensitization (SPTQ), eosinophil counts and a measure of lung function FEV(1)/H(2) (forced expiratory volume in one second divided by height square). Sex-stratified univariate and bivariate linkage analyses were conducted in 295 families from the Epidemiological study on the Genetics and Environment of Asthma study. We found genome-wide significant evidence for a male-specific pleiotropic QTL (quantitative trait loci) on 5q31 (P=7 x 10(-9)) influencing both FEV(1)/H(2) and SPTQ and for a female-specific pleiotropic QTL on 11q23 underlying SPTQ and immunoglobulin E (P=2 x 10(-5)). Three other sex-specific regions of linkage were detected for eosinophil: 4q24 and 22q13 in females, and 3p25 in males. Further, bivariate association analysis of FEV(1)/H(2) and SPTQ with 5q31 candidate genes in males showed a significant association with two single-nucleotide polymorphisms within IL9 gene, rs2069885 and rs2069882 (P=0.02 and P=0.002, respectively, after Bonferroni's correction). This study underlies the importance of taking into account complex mechanisms, such as heterogeneity according to sex and pleiotropy to unravel the genes involved in asthma phenotypes. | lld:pubmed |
| pubmed-article:19536153 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19536153 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19536153 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19536153 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19536153 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19536153 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19536153 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:19536153 | pubmed:issn | 1476-5470 | lld:pubmed |
| pubmed-article:19536153 | pubmed:author | pubmed-author:KauffmannFF | lld:pubmed |
| pubmed-article:19536153 | pubmed:author | pubmed-author:DemenaisFF | lld:pubmed |
| pubmed-article:19536153 | pubmed:author | pubmed-author:LathropMM | lld:pubmed |
| pubmed-article:19536153 | pubmed:author | pubmed-author:GormandFF | lld:pubmed |
| pubmed-article:19536153 | pubmed:author | pubmed-author:UlgenAA | lld:pubmed |
| pubmed-article:19536153 | pubmed:author | pubmed-author:BouzigonEE | lld:pubmed |
| pubmed-article:19536153 | pubmed:author | pubmed-author:DizierM-HMH | lld:pubmed |
| pubmed-article:19536153 | pubmed:author | pubmed-author:EGEA... | lld:pubmed |
| pubmed-article:19536153 | pubmed:author | pubmed-author:CordaEE | lld:pubmed |
| pubmed-article:19536153 | pubmed:author | pubmed-author:AschardHH | lld:pubmed |
| pubmed-article:19536153 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19536153 | pubmed:volume | 10 | lld:pubmed |
| pubmed-article:19536153 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19536153 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19536153 | pubmed:pagination | 559-65 | lld:pubmed |
| pubmed-article:19536153 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:19536153 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19536153 | pubmed:articleTitle | Sex-specific effect of IL9 polymorphisms on lung function and polysensitization. | lld:pubmed |
| pubmed-article:19536153 | pubmed:affiliation | INSERM, U946, Fondation Jean Dausset/CEPH, Paris 75010, France. hugues.aschard@inserm.fr | lld:pubmed |
| pubmed-article:19536153 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19536153 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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