Source:http://linkedlifedata.com/resource/pubmed/id/19536153
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
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| pubmed:dateCreated |
2009-9-2
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| pubmed:abstractText |
Sex differences in asthma-associated phenotypes are well known but the genetic factors that may account for these differences have received little attention. This study aimed to characterize sex-specific and pleiotropic genetic factors underlying four quantitative phenotypes involved in the main asthma physiopathological pathways: immunoglobulin E levels, a measure of polysensitization (SPTQ), eosinophil counts and a measure of lung function FEV(1)/H(2) (forced expiratory volume in one second divided by height square). Sex-stratified univariate and bivariate linkage analyses were conducted in 295 families from the Epidemiological study on the Genetics and Environment of Asthma study. We found genome-wide significant evidence for a male-specific pleiotropic QTL (quantitative trait loci) on 5q31 (P=7 x 10(-9)) influencing both FEV(1)/H(2) and SPTQ and for a female-specific pleiotropic QTL on 11q23 underlying SPTQ and immunoglobulin E (P=2 x 10(-5)). Three other sex-specific regions of linkage were detected for eosinophil: 4q24 and 22q13 in females, and 3p25 in males. Further, bivariate association analysis of FEV(1)/H(2) and SPTQ with 5q31 candidate genes in males showed a significant association with two single-nucleotide polymorphisms within IL9 gene, rs2069885 and rs2069882 (P=0.02 and P=0.002, respectively, after Bonferroni's correction). This study underlies the importance of taking into account complex mechanisms, such as heterogeneity according to sex and pleiotropy to unravel the genes involved in asthma phenotypes.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Sep
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| pubmed:issn |
1476-5470
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
10
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
559-65
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| pubmed:dateRevised |
2010-11-18
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| pubmed:meshHeading |
pubmed-meshheading:19536153-Adolescent,
pubmed-meshheading:19536153-Asthma,
pubmed-meshheading:19536153-Bronchial Hyperreactivity,
pubmed-meshheading:19536153-Cell Count,
pubmed-meshheading:19536153-Child,
pubmed-meshheading:19536153-Chromosome Mapping,
pubmed-meshheading:19536153-Chromosomes, Human, Pair 11,
pubmed-meshheading:19536153-Chromosomes, Human, Pair 22,
pubmed-meshheading:19536153-Chromosomes, Human, Pair 4,
pubmed-meshheading:19536153-Eosinophils,
pubmed-meshheading:19536153-Female,
pubmed-meshheading:19536153-Forced Expiratory Volume,
pubmed-meshheading:19536153-Genetic Linkage,
pubmed-meshheading:19536153-Genome, Human,
pubmed-meshheading:19536153-Genome-Wide Association Study,
pubmed-meshheading:19536153-Genotype,
pubmed-meshheading:19536153-Humans,
pubmed-meshheading:19536153-Immunoglobulin E,
pubmed-meshheading:19536153-Interleukin-9,
pubmed-meshheading:19536153-Lung,
pubmed-meshheading:19536153-Male,
pubmed-meshheading:19536153-Microsatellite Repeats,
pubmed-meshheading:19536153-Phenotype,
pubmed-meshheading:19536153-Polymorphism, Single Nucleotide,
pubmed-meshheading:19536153-Quantitative Trait Loci,
pubmed-meshheading:19536153-Respiratory Function Tests,
pubmed-meshheading:19536153-Sex Factors
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| pubmed:year |
2009
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| pubmed:articleTitle |
Sex-specific effect of IL9 polymorphisms on lung function and polysensitization.
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| pubmed:affiliation |
INSERM, U946, Fondation Jean Dausset/CEPH, Paris 75010, France. hugues.aschard@inserm.fr
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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