Source:http://linkedlifedata.com/resource/pubmed/id/19520550
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2009-8-24
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| pubmed:abstractText |
Inflammatory mechanisms are involved in the pathogenesis of epilepsy. Vice versa, immune functions are regulated by the brain. We measured postictal changes in serum levels of the immuno-modulating cytokines IL-1beta, IL-6 and TNFalpha in patients with well-defined temporal lobe epilepsy (TLE) and determined modifying factors. Serum levels of IL-1beta, IL-6 and TNFalpha were quantified by ELISA at baseline as well as immediately, 1h and 24h after a complex partial (CPS) or secondary generalized tonic-clonic seizure (GTCS) during video-EEG monitoring in 25 patients suffering from temporal epilepsy. IL-6 increased by 51% immediately after the seizure (p<0.01) and remained elevated for 24h. This increase lacked in patients with hippocampal sclerosis (HS; n=16, mean increase 28%, p>0.5, vs. 112%, p<0.01 in patients without HS). IL-6 levels were higher after right-sided seizures as compared to left-sided seizures 24h after the seizure (8.7pg/mL vs. 3.4pg/mL, p<0.05). In patients taking valproate (VPA, n=9), the levels of IL-1beta were higher as compared to patients not treated with VPA. The results suggest a relationship between the cytokine system and characteristics of TLE such as side and pathology.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
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| pubmed:issn |
1872-6844
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| pubmed:author |
pubmed-author:BauerSebastianS,
pubmed-author:CarlsonEvaE,
pubmed-author:CepokSabineS,
pubmed-author:HemmerBernhardB,
pubmed-author:KöllerMartinaM,
pubmed-author:LorenzRüdigerR,
pubmed-author:NowakMareikeM,
pubmed-author:OertelWolfgang HWH,
pubmed-author:RosenowFelixF,
pubmed-author:Todorova-RudolphAneliaA
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| pubmed:issnType |
Electronic
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| pubmed:volume |
86
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
82-8
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| pubmed:meshHeading |
pubmed-meshheading:19520550-Adolescent,
pubmed-meshheading:19520550-Adult,
pubmed-meshheading:19520550-Cytokines,
pubmed-meshheading:19520550-Electroencephalography,
pubmed-meshheading:19520550-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:19520550-Epilepsy, Temporal Lobe,
pubmed-meshheading:19520550-Female,
pubmed-meshheading:19520550-Functional Laterality,
pubmed-meshheading:19520550-Humans,
pubmed-meshheading:19520550-Interleukin-1beta,
pubmed-meshheading:19520550-Interleukin-6,
pubmed-meshheading:19520550-Male,
pubmed-meshheading:19520550-Middle Aged,
pubmed-meshheading:19520550-Retrospective Studies,
pubmed-meshheading:19520550-Statistics, Nonparametric,
pubmed-meshheading:19520550-Time Factors,
pubmed-meshheading:19520550-Tumor Necrosis Factor-alpha,
pubmed-meshheading:19520550-Video Recording,
pubmed-meshheading:19520550-Young Adult
|
| pubmed:year |
2009
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| pubmed:articleTitle |
Etiology and site of temporal lobe epilepsy influence postictal cytokine release.
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| pubmed:affiliation |
Department of Neurology, University of Marburg, Marburg, Germany. bauerse@med.uni-marburg.de
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| pubmed:publicationType |
Journal Article
|