Linked Life Data

19514609

Source:http://linkedlifedata.com/resource/pubmed/id/19514609

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2009-6-11
pubmed:abstractText
Epidemiological data indicate twofold increase of low impact fractures (spine, hip, ribs, distal forearm, and shoulder) in patients on glucocorticoid treatment compared with untreated subjects. These risks are mainly independent of BMD and prevalent fracture. Early direct inhibitory effect ofglucocorticoid on bone formation and promotion of apoptosis of bone cells are thought to be the major mechanism of glucocorticoid-induced osteoporosis (GIO). Despite differences in pathogenesis of postmenopausal osteoporosis, GIO, and other types ofosteoporosis, the algorithm of treatment of GIO should be based on the assessment of the individual absolute risk of fracture (FRAX) according to the WHO recommendations. Glucocorticoid-induced bone loss should be prevented, and if present, should be treated. Considering long-term character of GIO, the bone anabolic therapy should be used at absolute risk of hip fracture of > or = 3%.
pubmed:commentsCorrections
pubmed:language
cze
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0042-773X
pubmed:author
pubmed:issnType
Print
pubmed:volume
55
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
448-54
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
[Algorithm of treatment of glucocorticoid induced osteoporosis--search for criteria].
pubmed:publicationType
Editorial, Comment, English Abstract