Linked Life Data

19502956

Source:http://linkedlifedata.com/resource/pubmed/id/19502956

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2009-6-8
pubmed:abstractText
Several animal models for xenogenic (xeno) graft versus host disease (GVHD) have been developed in immunodeficient mice, such as C.B-17-scid and nonobese diabetes (NOD)/severe combined immunodeficiency (SCID), by human peripheral blood mononuclear cell (hPBMC) transplantation. However, these models pose problems because they require sublethal total body irradiation of the mice and a large number of hPBMCs to induce GVHD, and the timing of onset of GVHD is also unstable. The aim of this study is to establish improved murine models of xeno-GVHD using novel immunodeficient NOD/Shi-scid IL2r gamma null (NOG) mice.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1534-6080
pubmed:author
pubmed:issnType
Electronic
pubmed:day
15
pubmed:volume
87
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1654-8
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Highly sensitive model for xenogenic GVHD using severe immunodeficient NOG mice.
pubmed:affiliation
Department of Laboratory Animal Research, Central Institute for Experimental Animals, Miyamae, Kawasaki, Japan. rito@ciea.or.jp
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't