Linked Life Data

1949926

Source:http://linkedlifedata.com/resource/pubmed/id/1949926

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7-8
pubmed:dateCreated
1991-11-25
pubmed:abstractText
We examined the relationship between serum concentrations of meperidine hydrochloride and analgesic response in postsurgical patients allowed to use patient-controlled analgesia (PCA) and compared these findings with those of patients receiving conventional intramuscular (IM) dosing. Six patients who had undergone abdominal surgery were randomly assigned to receive postoperative analgesia with either PCA or IM therapy. A sequence of five-point pain and sedation scores and serum meperidine concentrations were obtained in all patients the day after surgery. Minimum effective concentration (MEC) was defined as that concentration of meperidine at which patients felt pain relief as indicated by a decrease in pain rankings. The mean MEC for patients using PCA, 296 +/- 112 ng/mL, was significantly lower than the mean MEC in patients receiving IM dosing (551 +/- 164 ng/mL, p less than 0.05). The mean maximum change in meperidine concentrations in the PCA group, 177 +/- 88 ng/mL, was significantly lower than that of the IM group (484 +/- 125 ng/mL, p less than 0.05). Mean maximum changes in pain and sedation scores for patients in the PCA group were not significantly different from those of the IM group. During this investigation patients using PCA experienced smaller swings in meperidine concentrations than did patients receiving IM injections. MEC analysis suggests that PCA patients may experience pain relief at lower meperidine concentrations than those needed by IM patients.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1042-9611
pubmed:author
pubmed:issnType
Print
pubmed:volume
25
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
724-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Meperidine serum concentrations and analgesic response in postsurgical patients.
pubmed:affiliation
College of Pharmacy and Allied Health Professions, Wayne State University, Detroit, MI 48202.
pubmed:publicationType
Journal Article, Clinical Trial, Comparative Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't