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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
17
|
| pubmed:dateCreated |
1991-12-18
|
| pubmed:abstractText |
Immunosuppressive treatment with cyclophosphamide and prednisolone has markedly improved the prognosis of Wegener's granulomatosis (WG). In patients with WG the detection of anti-neutrophil-cytoplasmic autoantibodies (ANCA or ACPA) has become an important parameter to confirm or even routinely establish the diagnosis of WG over the past few years. From 1985 to 1990 we observed and treated 12 patients (5 males and 7 females) aged 14-64 years (mean 41.1 years) with WG. In the same time span an analysis of 35 patients with rapidly progressive glomerulonephritis showed that the octiology was idiopathic in the majority of cases (54.3%), but nevertheless 8 cases (22.8%) were caused by WG. In 9 out of 10 cases the ANCA test was positive; whereas in 8 out of 10 cases we found a close correlation between the serum level of ANCA and disease activity. However, extraordinarily high serum levels (titres up to 1:2560) were recorded in one patient with WG without any clinical symptoms, whilst another patient with severe symptoms of WG showed a titre of only 1:5. 10 out of 12 patients were successfully brought to remission under cyclophosphamide-cortisone treatment. 4 out of 10 patients with renal insufficiency have been retained on the chronic haemodialysis regimen. 2 patients, aged 31 and 51 years, died within 2-5 months after the onset of clinical symptoms of WG.
|
| pubmed:language |
ger
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0043-5325
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
103
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
528-32
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:1949812-Adolescent,
pubmed-meshheading:1949812-Adult,
pubmed-meshheading:1949812-Autoantibodies,
pubmed-meshheading:1949812-Autoimmune Diseases,
pubmed-meshheading:1949812-Azathioprine,
pubmed-meshheading:1949812-Cyclophosphamide,
pubmed-meshheading:1949812-Cytoplasm,
pubmed-meshheading:1949812-Drug Administration Schedule,
pubmed-meshheading:1949812-Drug Therapy, Combination,
pubmed-meshheading:1949812-Female,
pubmed-meshheading:1949812-Follow-Up Studies,
pubmed-meshheading:1949812-Glomerulonephritis, Membranoproliferative,
pubmed-meshheading:1949812-Humans,
pubmed-meshheading:1949812-Male,
pubmed-meshheading:1949812-Middle Aged,
pubmed-meshheading:1949812-Neutrophils,
pubmed-meshheading:1949812-Prednisolone,
pubmed-meshheading:1949812-Wegener Granulomatosis
|
| pubmed:year |
1991
|
| pubmed:articleTitle |
[Clinical experiences with Wegener's granulomatosis from the nephrologic viewpoint].
|
| pubmed:affiliation |
Medizinische Universitätsklinik, Karl-Franzens-Universität, Graz.
|
| pubmed:publicationType |
Journal Article,
English Abstract
|