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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2009-7-6
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pubmed:abstractText |
Costimulation via the PD-1 and B7-H1/B7-DC pathway regulates immunity. We investigated whether the PD-1/PD-L pathway is impaired in autoimmune diabetes. A progressive increase in the expression of PD-1 and B7-H1/B7-DC on T cells and APC, respectively, was observed in the pancreatic lymph nodes of female non-obese diabetic (NOD) mice as they developed diabetes. A significantly decreased expression of PD-1 and B7-H1/B7-DC on T cells and APC, respectively, was observed in the periphery of prediabetic NOD mice versus non-diabetic C57BL/6 strain. NOD islets also displayed a reduced capacity to upregulate B7-H1 following exposure to inflammatory cytokines. In vivo blocking studies in NOD/B7-2KONOD mice revealed that B7-H1 and B7-DC positively costimulate autoreactive CD4 and CD8 T cells and may co-operate with B7-2 to augment priming and expansion of naïve autoreactive T cells. In summary, these data suggest that diabetes susceptibility in NOD mice is associated with altered PD-1/PD-L availability.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD274,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD80,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation,
http://linkedlifedata.com/resource/pubmed/chemical/Apoptosis Regulatory Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cd274 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Ligands,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/PD-1 antigen, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Pdcd1lg2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Programmed Cell Death 1 Ligand 2...
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pubmed:status |
MEDLINE
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pubmed:issn |
1090-2163
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
258
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
161-71
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:19497561-Age Factors,
pubmed-meshheading:19497561-Animals,
pubmed-meshheading:19497561-Antigen-Presenting Cells,
pubmed-meshheading:19497561-Antigens, CD274,
pubmed-meshheading:19497561-Antigens, CD80,
pubmed-meshheading:19497561-Antigens, Differentiation,
pubmed-meshheading:19497561-Apoptosis Regulatory Proteins,
pubmed-meshheading:19497561-Diabetes Mellitus, Type 1,
pubmed-meshheading:19497561-Disease Progression,
pubmed-meshheading:19497561-Disease Susceptibility,
pubmed-meshheading:19497561-Female,
pubmed-meshheading:19497561-Ligands,
pubmed-meshheading:19497561-Lymph Nodes,
pubmed-meshheading:19497561-Membrane Glycoproteins,
pubmed-meshheading:19497561-Mice,
pubmed-meshheading:19497561-Mice, Inbred NOD,
pubmed-meshheading:19497561-Mice, Transgenic,
pubmed-meshheading:19497561-Pancreas,
pubmed-meshheading:19497561-Peptides,
pubmed-meshheading:19497561-Programmed Cell Death 1 Ligand 2 Protein,
pubmed-meshheading:19497561-Signal Transduction,
pubmed-meshheading:19497561-Spleen,
pubmed-meshheading:19497561-T-Lymphocytes
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pubmed:year |
2009
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pubmed:articleTitle |
Altered availability of PD-1/PD ligands is associated with the failure to control autoimmunity in NOD mice.
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pubmed:affiliation |
Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, United States. dyadav@ucsd.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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