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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2009-6-4
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pubmed:abstractText |
Preterm and term newborn infants show wide interindividual variability (IIV) in pharmacokinetic parameters of gentamicin. More extensive knowledge and use of predictive covariates could lead to faster attainment of therapeutic concentrations and a reduced need for concentration monitoring. This study was performed to characterize the population pharmacokinetics of gentamicin in preterm and term neonates and to identify and quantify relationships between patient characteristics and IIV. A secondary aim was to evaluate cystatin C as a marker for gentamicin clearance in this patient population.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0312-5963
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
48
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
253-63
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pubmed:meshHeading |
pubmed-meshheading:19492870-Age Factors,
pubmed-meshheading:19492870-Biological Markers,
pubmed-meshheading:19492870-Body Weight,
pubmed-meshheading:19492870-Cefuroxime,
pubmed-meshheading:19492870-Creatinine,
pubmed-meshheading:19492870-Cystatin C,
pubmed-meshheading:19492870-Drug Interactions,
pubmed-meshheading:19492870-Female,
pubmed-meshheading:19492870-Gentamicins,
pubmed-meshheading:19492870-Gestational Age,
pubmed-meshheading:19492870-Humans,
pubmed-meshheading:19492870-Indomethacin,
pubmed-meshheading:19492870-Infant,
pubmed-meshheading:19492870-Infant, Newborn,
pubmed-meshheading:19492870-Infant, Premature,
pubmed-meshheading:19492870-Male,
pubmed-meshheading:19492870-Nonlinear Dynamics,
pubmed-meshheading:19492870-Vancomycin
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pubmed:year |
2009
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pubmed:articleTitle |
Developmental pharmacokinetics of gentamicin in preterm and term neonates: population modelling of a prospective study.
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pubmed:affiliation |
Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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