Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11-12
pubmed:dateCreated
2009-6-3
pubmed:abstractText
Development of gastric cancer is a multistage, multifactorial process. This study determined the population attributable risk for environmental and genetic risk factors in development of gastric cancer. A 1:1 cancer case-control study was undertaken in Nanjing, Jiangsu Province, China. A conditional-logistic regression model was used to determine environmental and genetic risk factors and calculate attributable risk (AR%) for each environmental and genetic risk factor in gastric cancer. In addition, the summary attributable risk (sAR) for all of the risk factors among 503 cases of gastric cancer patients and controls was determined. The environmental risk factors for gastric cancer in the Nanjing area were family history of tumor, consumption of pickled food, engorgement after hunger, irregular dietary habits, and lack of fruit intake. The genetic risk factors included the following genotypes: CYP2E1 wild, NAT2 M1 mutation, NAT2 slow-acetylators, XRCC1 194 mutation, MTHFR A1298C mutation, and IL-1B mutation. Combining environmental and genetic risk factors, sAR was 76.34%. Data suggest that genetic polymorphisms and environmental risk factors play concurrent roles in the development of gastric cancer. The results of this study indicate preventive strategies to avoid development of gastric cancer based on identified genetic polymorphisms and control of environmental risk factors.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
1528-7394
pubmed:author
pubmed:issnType
Print
pubmed:volume
72
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
759-66
pubmed:dateRevised
2010-1-19
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Analysis and estimates of the attributable risk for environmental and genetic risk factors in gastric cancer in a Chinese population.
pubmed:affiliation
School of Public Health, Southeast University, Nanjing, China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't