Extracellular insulin affects insulin secretion from pancreatic beta-cells in an autocrine fashion, but the role of glucose in this signaling pathway remains unclear. This study was conducted to evaluate the glucose dependency of extracellular insulin-mediated regulation of insulin secretion and the potential underlying mechanism.
Department of Physiology, Keimyung University School of Medicine & Chronic Disease Research Center, 194, Dongsan-Dong, Jung-Gu, Daegu 700-712, South Korea.