Linked Life Data

19481442

Source:http://linkedlifedata.com/resource/pubmed/id/19481442

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2009-7-27
pubmed:abstractText
Functional neural circuit formation during postnatal development involves the elimination of early-formed redundant synapses. In the neonatal mouse cerebellum, each Purkinje cell is innervated by multiple climbing fibers (CFs). Their synaptic strengths are initially uniform but one CF strengthens relative to other CFs during the first postnatal week. Then the weaker CFs are eliminated during the second postnatal week. Projections from the retina to the lateral geniculate nucleus (LGN) undergo similar developmental changes, that is the elimination of the majority of inputs and strengthening of a few afferents that remain. Recent studies have clarified that in both cerebellum and LGN, synapse refinement consists of multiple phases and that distinct types of neural activity drive synaptic remodeling in each developmental phase.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1873-6882
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
154-61
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Synapse elimination in the central nervous system.
pubmed:affiliation
Department of Neurophysiology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan. mkano-tky@m.u-tokyo.ac.jp
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't