|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5
|
|
pubmed:dateCreated |
2009-5-29
|
|
pubmed:abstractText |
Enhanced sympathetic activation has a central role in the development of heart failure (HF). We assessed whether the alpha(2C)-adrenoceptor (Del322-325) polymorphism exclusively or in combination with a beta(1)-adrenoceptor (Arg389) polymorphism, each with known independent effects on sympathetic function, were associated with an increased risk of adverse events in HF.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
|
pubmed:issn |
1532-8414
|
|
pubmed:author |
pubmed-author:BallStephen GSG,
pubmed-author:BalmforthAnthony JAJ,
pubmed-author:De BoerRudolf ARA,
pubmed-author:GallowayStacey LSL,
pubmed-author:MaqboolAzharA,
pubmed-author:Merit-HF Study Group,
pubmed-author:SavvaJacquelineJ,
pubmed-author:Van VeldhuisenDirk JDJ,
pubmed-author:WestRobert MRM,
pubmed-author:WhiteHazel LHL,
pubmed-author:YuldashevaNadira YNY
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
15
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
435-41
|
|
pubmed:meshHeading |
pubmed-meshheading:19477404-Aged,
pubmed-meshheading:19477404-Alleles,
pubmed-meshheading:19477404-DNA,
pubmed-meshheading:19477404-Female,
pubmed-meshheading:19477404-Genotype,
pubmed-meshheading:19477404-Heart Failure,
pubmed-meshheading:19477404-Humans,
pubmed-meshheading:19477404-Male,
pubmed-meshheading:19477404-Polymorphism, Genetic,
pubmed-meshheading:19477404-Receptors, Adrenergic, alpha-2,
pubmed-meshheading:19477404-Receptors, Adrenergic, beta-1,
pubmed-meshheading:19477404-Risk Factors,
pubmed-meshheading:19477404-Sequence Analysis, DNA,
pubmed-meshheading:19477404-Severity of Illness Index
|
|
pubmed:year |
2009
|
|
pubmed:articleTitle |
Polymorphisms of adrenoceptors are not associated with an increased risk of adverse event in heart failure: a MERIT-HF substudy.
|
|
pubmed:affiliation |
Division of Cardiovascular and Neuronal Remodelling, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds, UK.
|
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't,
Multicenter Study
|
