Source:http://linkedlifedata.com/resource/pubmed/id/19472311
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2009-8-4
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| pubmed:abstractText |
It is increasingly clear that hepatocellular carcinoma (HCC) has a distinct microRNA (miRNA) expression profile that is involved in malignancy; however, little is known about how functional miRNA modulates the metastasis of hepatitis B virus (HBV)-related HCC (HBV-HCC). In the present study, we demonstrate that the levels of miRNA-143 (miR-143) are dramatically increased in metastatic HBV-HCC of both p21-HBx transgenic mice and HCC patients. Moreover, we show that overexpression of this miRNA is transcribed by nuclear factor kappa B (NF-kappaB) and favors liver tumor cell invasive and metastatic behavior. Intratumoral administration of miR-143 shows that high levels of miR-143 can significantly promote HCC metastasis in an athymic nude mouse model. An in vivo study that used p21-HBx transgenic mice also showed that local liver metastasis and distant lung metastasis are significantly inhibited by blocking miR-143. Additionally, fibronectin type III domain containing 3B (FNDC3B), which regulates cell motility, was identified as the direct and functional target of miR-143 both in vivo and in vitro. CONCLUSION: Up-regulation of miR-143 expression transcribed by NF-kappaB in HBV-HCC promotes cancer cell invasion/migration and tumor metastasis by repression of FNDC3B expression. The present study provides a better understanding of the specificity of the biological behavior and thus may be helpful in developing an effective treatment against HBV-HCC.
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| pubmed:commentsCorrections | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Fibronectins,
http://linkedlifedata.com/resource/pubmed/chemical/MIRN143 microRNA, human,
http://linkedlifedata.com/resource/pubmed/chemical/MicroRNAs,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/hepatitis B virus X protein
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| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
1527-3350
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| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:volume |
50
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
490-9
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| pubmed:dateRevised |
2009-9-2
|
| pubmed:meshHeading |
pubmed-meshheading:19472311-Adult,
pubmed-meshheading:19472311-Aged,
pubmed-meshheading:19472311-Animals,
pubmed-meshheading:19472311-Carcinoma, Hepatocellular,
pubmed-meshheading:19472311-Cell Line, Tumor,
pubmed-meshheading:19472311-Cell Movement,
pubmed-meshheading:19472311-Down-Regulation,
pubmed-meshheading:19472311-Female,
pubmed-meshheading:19472311-Fibronectins,
pubmed-meshheading:19472311-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:19472311-Hepatitis B, Chronic,
pubmed-meshheading:19472311-Humans,
pubmed-meshheading:19472311-Liver Neoplasms,
pubmed-meshheading:19472311-Male,
pubmed-meshheading:19472311-Mice,
pubmed-meshheading:19472311-Mice, Nude,
pubmed-meshheading:19472311-Mice, Transgenic,
pubmed-meshheading:19472311-MicroRNAs,
pubmed-meshheading:19472311-Middle Aged,
pubmed-meshheading:19472311-NF-kappa B,
pubmed-meshheading:19472311-Neoplasm Invasiveness,
pubmed-meshheading:19472311-Neoplasm Metastasis,
pubmed-meshheading:19472311-Trans-Activators,
pubmed-meshheading:19472311-Up-Regulation
|
| pubmed:year |
2009
|
| pubmed:articleTitle |
Up-regulated microRNA-143 transcribed by nuclear factor kappa B enhances hepatocarcinoma metastasis by repressing fibronectin expression.
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| pubmed:affiliation |
Department of Medical Genetics, Second Military Medical University, Shanghai, PR China.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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