Linked Life Data

19463954

Source:http://linkedlifedata.com/resource/pubmed/id/19463954

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2009-6-22
pubmed:abstractText
Olfactory sensory neurons (OSNs) expressing the same odorant receptor (OR) gene are generally widely dispersed throughout the olfactory epithelium (OE). In contrast, OSNs expressing any member from the special OR37 subfamily are concentrated in a small patch in the centre of the OE. To evaluate whether transcription of OR37 genes is only possible in the patch region, or if they can generally be chosen also in non-appropriate areas, a transgenic approach was employed that permanently labelled all cells which ever transcribed a representative OR37 gene. It was found that - in addition to cells inside the patch - numerous cells outside were labelled, indicating that they had transcribed the OR37 gene, but then turned it off while choosing another OR gene. Permanent expression of the OR37 gene was exclusively maintained in the patch. The results suggest that mechanisms acting downstream of an initial OR gene choice restrict OR37 expression to the patch.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1095-9327
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
41
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
474-85
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
The patch-like pattern of OR37 receptors is formed by turning off gene expression in non-appropriate areas.
pubmed:affiliation
University of Hohenheim, Institute of Physiology, Garbenstrasse 30, 70593 Stuttgart, Germany. strotman@uni-hohenheim.de
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't