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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2009-8-12
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pubmed:abstractText |
Interstitial cells of Cajal (ICC) play important roles in autonomic gut motility as electrical pacemakers and mediators of neural regulation of smooth muscle functions. Insufficiency of ICC has been reported in a wide range of gut dysmotilities. Thus, restoration of ICC may be a therapeutic modality in these diseases. Here we provide evidence that transplanted bone marrow (BM) cells can restore gut dysmotility in part via transdifferentiation to ICC.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0944-1174
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
44
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
834-41
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:19458897-Animals,
pubmed-meshheading:19458897-Bone Marrow Transplantation,
pubmed-meshheading:19458897-Disease Models, Animal,
pubmed-meshheading:19458897-Female,
pubmed-meshheading:19458897-Gastric Emptying,
pubmed-meshheading:19458897-Gastrointestinal Motility,
pubmed-meshheading:19458897-Immunohistochemistry,
pubmed-meshheading:19458897-Male,
pubmed-meshheading:19458897-Mice,
pubmed-meshheading:19458897-Mice, Inbred C57BL,
pubmed-meshheading:19458897-Mice, Mutant Strains,
pubmed-meshheading:19458897-Mice, Transgenic,
pubmed-meshheading:19458897-Microscopy, Immunoelectron,
pubmed-meshheading:19458897-Proto-Oncogene Proteins c-kit
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pubmed:year |
2009
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pubmed:articleTitle |
Restoration of gut motility in Kit-deficient mice by bone marrow transplantation.
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pubmed:affiliation |
Department of Gastroenterology and Hepatology (K1), Osaka University Graduate School of Medicine, Suita, Osaka, Japan. sishii@gh.med.osaka-u.ac.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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