Linked Life Data

19457449

Source:http://linkedlifedata.com/resource/pubmed/id/19457449

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2009-7-27
pubmed:abstractText
Frailty is an important geriatric syndrome that predicts disability and mortality. Substantial evidence suggests that inflammation marked by elevated IL-6 levels and total white blood cell (WBC) counts contribute to this syndrome. However, the relationships of WBC subpopulations, the important inflammatory and immune cells, with frailty have not been investigated. To address this important question, we conducted cross-sectional polytomous logistic regression analyses evaluating associations between baseline WBC differential counts and prevalent frailty (defined by the validated Fried's criteria) of 558 disabled women aged 65-101 years and 548 women aged 70-79 living in the community, both from the Women's Health and Aging Studies. The results showed that high neutrophil and monocyte counts were associated with frailty in disabled older women, albeit these associations did not reach statistical significance in women aged 70-79, adjusting for age, race, education, body mass index, smoking, and antibiotic use. In addition, the identified associations were independent of IL-6. No significant associations of lymphocyte, eosinophil, or basophil counts with frailty were observed. These findings provide initial insight into potential roles of neutrophils and monocytes in the pathogenesis of frailty and a basis for further investigation into their function and regulation in frail older women.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1873-6815
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
44
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
511-6
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Associations of neutrophil and monocyte counts with frailty in community-dwelling disabled older women: results from the Women's Health and Aging Studies I.
pubmed:affiliation
Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, 5505 Hopkins Bayview Circle, Baltimore, MD 21224, USA. sleng1@jhmi.edu
pubmed:publicationType
Journal Article, Evaluation Studies