Source:http://linkedlifedata.com/resource/pubmed/id/19454687
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|---|---|
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| lifeskim:mentions |
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umls-concept:C1706817,
umls-concept:C2911692
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| pubmed:issue |
11
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| pubmed:dateCreated |
2009-5-20
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| pubmed:abstractText |
We have cloned the macrophage migration inhibitory factor (MIF)-like protein (Anisakis simplex (As)-MIF) from larvae of the whale worm (Anisakis simplex third-stage larvae). Asthma was induced in the mice using OVA/alum, with or without various concentrations of rAs-MIF treatment before OVA/alum challenge. Treatment with rAs-MIF coupled with OVA/alum during the challenge period induced a complete inhibition of eosinophilia and goblet cell hyperplasia within the lung and profoundly ameliorated the development of lung hyperreactivity. Also, rAs-MIF was shown to reduce profoundly the quantity of Th2-related cytokines (IL-4, IL-5, and IL-13) in the bronchial alveolar lavage fluid and allergen-specific IgG2a in sera. IL-10 and TGF-beta levels in the bronchoalveolar lavage fluid of the rAs-MIF-treated group were significantly higher than in the other groups. Additionally, CD4(+)CD25(+)Foxp3(+) T cells (regulatory T) were recruited to the spleen and lungs of the rAs-MIF-treated mice, but this recruitment was inhibited by anti-rAs-MIF Ab.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Jun
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| pubmed:issn |
1550-6606
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:day |
1
|
| pubmed:volume |
182
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
6907-14
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| pubmed:meshHeading |
pubmed-meshheading:19454687-Animals,
pubmed-meshheading:19454687-Anisakis,
pubmed-meshheading:19454687-Asthma,
pubmed-meshheading:19454687-Bronchoalveolar Lavage Fluid,
pubmed-meshheading:19454687-Chemotaxis, Leukocyte,
pubmed-meshheading:19454687-Cytokines,
pubmed-meshheading:19454687-Disease Models, Animal,
pubmed-meshheading:19454687-Inflammation,
pubmed-meshheading:19454687-Lung,
pubmed-meshheading:19454687-Macrophage Migration-Inhibitory Factors,
pubmed-meshheading:19454687-Mice,
pubmed-meshheading:19454687-Spleen,
pubmed-meshheading:19454687-T-Lymphocytes, Regulatory,
pubmed-meshheading:19454687-Th2 Cells
|
| pubmed:year |
2009
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| pubmed:articleTitle |
Macrophage migration inhibitory factor homologs of anisakis simplex suppress Th2 response in allergic airway inflammation model via CD4+CD25+Foxp3+ T cell recruitment.
|
| pubmed:affiliation |
Department of Parasitology, School of Medicine, Pusan National University Busan, Busan, Korea.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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