Source:http://linkedlifedata.com/resource/pubmed/id/19448163
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2009-5-18
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| pubmed:abstractText |
In this study, we assessed the potential role of the TT genotype of the gene of the methylenetetrahydrofolate reductase for the manifestation of thrombotic microangiopathies, enrolling 40 affected patients (mean age [+/- standard deviation] 35 +/- 11 years). As a result, the methylenetetrahydrofolate reductase 677TT genotype was more prevalent in patients with thrombotic microangiopathies compared with controls (adjusted odds ratio = 2.58, 95% confidence interval = 1.2-5.7, P = .018), particularly in those suffering from the hemolytic uremic syndrome. A hemolytic more severe clinical course of thrombotic microangiopathies in carriers of the methylenetetrahydrofolate reductase 677TT genotype was not observed. In summary, our findings suggest a significant influence of the methylenetetrahydrofolate reductase genotype on the manifestation of thrombotic microangiopathies. The 677 TT genotype of this polymorphism appears to be a risk factor for manifestation of these rare thrombotic disorders, possibly explained by endothelial activation and increased oxidative stress.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:issn |
1076-0296
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
15
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
283-8
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| pubmed:meshHeading |
pubmed-meshheading:19448163-Adult,
pubmed-meshheading:19448163-Case-Control Studies,
pubmed-meshheading:19448163-Female,
pubmed-meshheading:19448163-Gene Frequency,
pubmed-meshheading:19448163-Genetic Predisposition to Disease,
pubmed-meshheading:19448163-Hemolytic-Uremic Syndrome,
pubmed-meshheading:19448163-Humans,
pubmed-meshheading:19448163-Male,
pubmed-meshheading:19448163-Methylenetetrahydrofolate Reductase (NADPH2),
pubmed-meshheading:19448163-Middle Aged,
pubmed-meshheading:19448163-Odds Ratio,
pubmed-meshheading:19448163-Phenotype,
pubmed-meshheading:19448163-Pilot Projects,
pubmed-meshheading:19448163-Polymorphism, Genetic,
pubmed-meshheading:19448163-Purpura, Thrombotic Thrombocytopenic,
pubmed-meshheading:19448163-Risk Assessment,
pubmed-meshheading:19448163-Risk Factors,
pubmed-meshheading:19448163-Severity of Illness Index,
pubmed-meshheading:19448163-Young Adult
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| pubmed:articleTitle |
The TT genotype of the C677T polymorphism in the methylentetrahydrofolate reductase as a risk factor in thrombotic microangiopathies: results from a pilot study.
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| pubmed:affiliation |
Department of Hemostasis and Transfusion Medicine, Heinrich Heine University Medical Center, Dusseldorf, Germany. sucker@med.uni-duesseldorf.de
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| pubmed:publicationType |
Journal Article
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