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rdf:type |
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lifeskim:mentions |
umls-concept:C0003595,
umls-concept:C0007328,
umls-concept:C0017431,
umls-concept:C0027051,
umls-concept:C0035647,
umls-concept:C0052198,
umls-concept:C0086045,
umls-concept:C0205419,
umls-concept:C0442796,
umls-concept:C1280500,
umls-concept:C1416919,
umls-concept:C1709059
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pubmed:dateCreated |
2009-6-2
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pubmed:abstractText |
The R952Q variant in the low density lipoprotein receptor-related protein 8 (LRP8)/apolipoprotein E receptor 2 (ApoER2) gene has been recently associated with familial and premature myocardial infarction (MI) by means of genome-wide linkage scan/association studies. We were interested in the possible interaction of the R952Q variant with another established cardiovascular genetic risk factor belonging to the same pathway, namely apolipoprotein E (APOE) epsilon2/epsilon3/epsilon4 genotype, in modulating apolipoprotein E (ApoE) plasma levels and risk of MI.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439088-10984565,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439088-11152697,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439088-11882522,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439088-12642066,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439088-14563827,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439088-14681304,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439088-14732905,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439088-15262670,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439088-15769795,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439088-15827760,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439088-16671834,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439088-16725309,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439088-16729847,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439088-17470198,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439088-17847002,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439088-17878422,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439088-18485085,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439088-18489431,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439088-18592168,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439088-2987927,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19439088-8626535
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1471-2350
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pubmed:author |
pubmed-author:BassiAntonellaA,
pubmed-author:BustiFabianaF,
pubmed-author:CorrocherRobertoR,
pubmed-author:FrisoSimonettaS,
pubmed-author:GirelliDomenicoD,
pubmed-author:HuYingY,
pubmed-author:JooFF,
pubmed-author:MartinelliNicolaN,
pubmed-author:PalR SRS,
pubmed-author:PignattiPier FrancoPF,
pubmed-author:PizzoloFrancescaF,
pubmed-author:ShenGong-QingGQ,
pubmed-author:TrabettiElisabettaE,
pubmed-author:WangQing KennethQK
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pubmed:issnType |
Electronic
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
41
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:19439088-Aged,
pubmed-meshheading:19439088-Apolipoprotein E2,
pubmed-meshheading:19439088-Apolipoprotein E3,
pubmed-meshheading:19439088-Apolipoprotein E4,
pubmed-meshheading:19439088-Case-Control Studies,
pubmed-meshheading:19439088-Cohort Studies,
pubmed-meshheading:19439088-Female,
pubmed-meshheading:19439088-Genetic Predisposition to Disease,
pubmed-meshheading:19439088-Genetic Variation,
pubmed-meshheading:19439088-Genome-Wide Association Study,
pubmed-meshheading:19439088-Genotype,
pubmed-meshheading:19439088-Humans,
pubmed-meshheading:19439088-Italy,
pubmed-meshheading:19439088-LDL-Receptor Related Proteins,
pubmed-meshheading:19439088-Male,
pubmed-meshheading:19439088-Middle Aged,
pubmed-meshheading:19439088-Myocardial Infarction,
pubmed-meshheading:19439088-Receptors, Lipoprotein,
pubmed-meshheading:19439088-Risk Factors
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pubmed:year |
2009
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pubmed:articleTitle |
Additive effect of LRP8/APOER2 R952Q variant to APOE epsilon2/epsilon3/epsilon4 genotype in modulating apolipoprotein E concentration and the risk of myocardial infarction: a case-control study.
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pubmed:affiliation |
Department of Clinical and Experimental Medicine, University of Verona, Verona, Italy. nicola.martinelli@univr.it
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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