Linked Life Data

19438247

Source:http://linkedlifedata.com/resource/pubmed/id/19438247

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2009-6-12
pubmed:abstractText
Ion mobility spectrometry (IMS) has been increasingly employed in a number of applications. When coupled to mass spectrometry (MS), IMS becomes a powerful analytical tool for separating complex samples and investigating molecular structure. Therefore, improvements in IMS-MS instrumentation, e.g., IMS resolving power and sensitivity, are highly desirable. Implementation of an ion trap for accumulation and pulsed ion injection to IMS based on the ion funnel has provided considerably increased ion currents and thus a basis for improved sensitivity and measurement throughput. However, large ion populations may manifest Coulombic effects contributing to the spatial dispersion of ions traveling in the IMS drift tube and reduction in the IMS resolving power. In this study, we present an analysis of Coulombic effects on IMS resolution. Basic relationships have been obtained for the spatial evolution of ion packets due to Coulombic repulsion. The analytical relationships were compared with results of a computer model that simulates IMS operation based on a first principles approach. Initial experimental results reported here are consistent with the computer modeling. A noticeable decrease in the IMS resolving power was observed for ion populations of >10,000 elementary charges. The optimum IMS operation conditions which would minimize the Coulombic effects are discussed.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/19438247-11128937, http://linkedlifedata.com/resource/pubmed/commentcorrection/19438247-11293699, http://linkedlifedata.com/resource/pubmed/commentcorrection/19438247-15889926, http://linkedlifedata.com/resource/pubmed/commentcorrection/19438247-16383309, http://linkedlifedata.com/resource/pubmed/commentcorrection/19438247-16771547, http://linkedlifedata.com/resource/pubmed/commentcorrection/19438247-16808456, http://linkedlifedata.com/resource/pubmed/commentcorrection/19438247-17081049, http://linkedlifedata.com/resource/pubmed/commentcorrection/19438247-17305309, http://linkedlifedata.com/resource/pubmed/commentcorrection/19438247-17512752, http://linkedlifedata.com/resource/pubmed/commentcorrection/19438247-17850113, http://linkedlifedata.com/resource/pubmed/commentcorrection/19438247-18166021, http://linkedlifedata.com/resource/pubmed/commentcorrection/19438247-18200615, http://linkedlifedata.com/resource/pubmed/commentcorrection/19438247-18582088, http://linkedlifedata.com/resource/pubmed/commentcorrection/19438247-18683951
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1520-6882
pubmed:author
pubmed:issnType
Electronic
pubmed:day
15
pubmed:volume
81
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4778-87
pubmed:dateRevised
2011-1-25
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Coulombic effects in ion mobility spectrometry.
pubmed:affiliation
Biological Sciences Division, Pacific Northwest National Laboratory, P.O. Box 999, Richland, Washington 99352, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, N.I.H., Extramural