Linked Life Data

19434547

Source:http://linkedlifedata.com/resource/pubmed/id/19434547

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2009-5-12
pubmed:abstractText
The emerging research on biomarkers in alcohol dependence has lead to a deeper understanding of the neurobiological mechanisms in alcoholism. The molecular networks and the pathophysiological circuits are complex and not completely unrevealed up to now. One of the most interesting biomarkers described to play an important role in alcohol dependence is the amino-acid homocysteine, which has particularly been linked with brain atrophy and withdrawal seizures. However, the molecular networks of homocysteine are complex and include an important impact on epigenetic regulation via homocysteine's action as a methyl-group donator in human metabolism. So, alterations in human homocysteine levels can influence DNA-methylation of specific gene areas which may change expression and synthesis of proteins possibly important for the genesis and maintenance of alcohol dependence.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1439-0795
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
42 Suppl 1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S102-9
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Homocysteine, alcoholism and its molecular networks.
pubmed:affiliation
Department of Psychiatry, Socialpsychiatry and Psychotherapy, Medical School Hannover, Germany. bleich.stefan@mh-hannover.de
pubmed:publicationType
Journal Article, Review