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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1991-12-6
|
| pubmed:abstractText |
Fifty six children with a birth weight of less than 1500 g and gestational age less than 34 weeks were studied at a mean age of 7.7 years. All had required mechanical ventilation, 36 suffered from hyaline membrane disease, 17 from atelectasis and three from pneumonia. Of these patients 37 developed broncho-pulmonary dysplasia (BPD). The study included skin prick test, measurement of ciliary beat frequency, chest X-ray, whole-body plethysmography and histamine challenge. Eight patients suffered from recurrent pulmonary infections up to the age of 4 years. Eleven children had a positive skin prick test. Three suffered from allergic asthma and six from hay-fever. The family history of atopy in these premature infants was no different from that of the general population. Ciliary beat frequency was normal in all cases (frequency: 11.8 +/- 1.8 Hz). In 34 patients X-rays showed minimal changes (peribronchial thickening n = 6, mild emphysema n = 28). Pulmonary function was normal except for an increase of thoracic gas volume which was correlated to grade of BPD according to Northway. There was a significant correlation between oxygen-score and radiological stage of BPD (r = 0.7). Histamine challenge showed hyperresponsiveness in 53% of the children. Eight patients showed a threshold similar of mild asthma (less than 1000 micrograms histamine per ml). The degree of airway hyperreactivity was correlated to the grade of BPD (r = 0.7; p less than 0.01) and the oxygen-score (r = -0.63; p less than 0.05). The oxygen-score may be considered a predictor of hyperresponsiveness and pulmonary outcome in later childhood.
|
| pubmed:language |
ger
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0300-8630
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
203
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
366-71
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:1942944-Bronchial Hyperreactivity,
pubmed-meshheading:1942944-Bronchopulmonary Dysplasia,
pubmed-meshheading:1942944-Child,
pubmed-meshheading:1942944-Follow-Up Studies,
pubmed-meshheading:1942944-Humans,
pubmed-meshheading:1942944-Hyaline Membrane Disease,
pubmed-meshheading:1942944-Infant, Low Birth Weight,
pubmed-meshheading:1942944-Infant, Newborn,
pubmed-meshheading:1942944-Infant, Premature,
pubmed-meshheading:1942944-Intermittent Positive-Pressure Ventilation,
pubmed-meshheading:1942944-Respiratory Function Tests,
pubmed-meshheading:1942944-Respiratory Hypersensitivity,
pubmed-meshheading:1942944-Skin Tests
|
| pubmed:articleTitle |
[Pulmonary sequelae of long-term ventilation of very low birth weight premature infants. Results of a follow-up study of 6-to-9-year-old children].
|
| pubmed:affiliation |
Zentrum der Kinderheilkunde, Johann Wolfgang Goethe-Universität, Frankfurt/Main.
|
| pubmed:publicationType |
Journal Article,
English Abstract
|