Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2009-5-8
pubmed:abstractText
DNA damage in Escherichia coli evokes a response mechanism called the SOS response. The genetic circuit of this mechanism includes the genes recA and lexA, which regulate each other via a mixed feedback loop involving transcriptional regulation and protein-protein interaction. Under normal conditions, recA is transcriptionally repressed by LexA, which also functions as an auto-repressor. In presence of DNA damage, RecA proteins recognize stalled replication forks and participate in the DNA repair process. Under these conditions, RecA marks LexA for fast degradation. Generally, such mixed feedback loops are known to exhibit either bi-stability or a single steady state. However, when the dynamics of the SOS system following DNA damage was recently studied in single cells, ordered peaks were observed in the promoter activity of both genes (Friedman et al., 2005, PLoS Biol. 3(7):e238). This surprising phenomenon was masked in previous studies of cell populations. Previous attempts to explain these results harnessed additional genes to the system and deployed complex deterministic mathematical models that were only partially successful in explaining the results.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/19424504-10850721, http://linkedlifedata.com/resource/pubmed/commentcorrection/19424504-12045091, http://linkedlifedata.com/resource/pubmed/commentcorrection/19424504-12399590, http://linkedlifedata.com/resource/pubmed/commentcorrection/19424504-12417193, http://linkedlifedata.com/resource/pubmed/commentcorrection/19424504-15001784, http://linkedlifedata.com/resource/pubmed/commentcorrection/19424504-15095986, http://linkedlifedata.com/resource/pubmed/commentcorrection/19424504-15715985, http://linkedlifedata.com/resource/pubmed/commentcorrection/19424504-15954802, http://linkedlifedata.com/resource/pubmed/commentcorrection/19424504-16360033, http://linkedlifedata.com/resource/pubmed/commentcorrection/19424504-17364684, http://linkedlifedata.com/resource/pubmed/commentcorrection/19424504-17412705, http://linkedlifedata.com/resource/pubmed/commentcorrection/19424504-17434938, http://linkedlifedata.com/resource/pubmed/commentcorrection/19424504-18599789, http://linkedlifedata.com/resource/pubmed/commentcorrection/19424504-2108251, http://linkedlifedata.com/resource/pubmed/commentcorrection/19424504-3900062, http://linkedlifedata.com/resource/pubmed/commentcorrection/19424504-6410076, http://linkedlifedata.com/resource/pubmed/commentcorrection/19424504-7709802
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1932-6203
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
e5363
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Stochastic analysis of the SOS response in Escherichia coli.
pubmed:affiliation
Department of Molecular Genetics and Biotechnology, Faculty of Medicine, The Hebrew University, Jerusalem, Israel. yshimoni@phys.huji.ac.il
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't