Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
14
pubmed:dateCreated
2009-6-24
pubmed:abstractText
Bilirubin, resulting largely from the turnover of hemoglobin, is found in the plasma in two main forms: unconjugated or conjugated with glucuronic acid. Unconjugated bilirubin is transported into hepatocytes. There, it is glucuronidated by UGT1A1 and secreted into the bile canaliculi. We report a genome wide association scan in 4300 Sardinian individuals for total serum bilirubin levels. In addition to the two known loci previously involved in the regulation of bilirubin levels, UGT1A1 (P = 6.2 x 10(-62)) and G6PD (P = 2.5 x 10(-8)), we observed a strong association on chromosome 12 within the SLCO1B3 gene (P = 3.9 x 10(-9)). Our findings were replicated in an independent sample of 1860 Sardinians and in 832 subjects from the Old Order Amish (combined P < 5 x 10(-14)). We also show that SLC01B3 variants contribute to idiopathic mild unconjugated hyperbilirubinemia. Thus, SLC01B3 appears to be involved in the regulation of serum bilirubin levels in healthy individuals and in some bilirubin-related disorders that are only partially explained by other known gene variants.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/19419973-10091404, http://linkedlifedata.com/resource/pubmed/commentcorrection/19419973-10192462, http://linkedlifedata.com/resource/pubmed/commentcorrection/19419973-10358072, http://linkedlifedata.com/resource/pubmed/commentcorrection/19419973-10779507, http://linkedlifedata.com/resource/pubmed/commentcorrection/19419973-11134001, http://linkedlifedata.com/resource/pubmed/commentcorrection/19419973-11731797, http://linkedlifedata.com/resource/pubmed/commentcorrection/19419973-12130747, http://linkedlifedata.com/resource/pubmed/commentcorrection/19419973-16934002, http://linkedlifedata.com/resource/pubmed/commentcorrection/19419973-17658951, http://linkedlifedata.com/resource/pubmed/commentcorrection/19419973-17924335, http://linkedlifedata.com/resource/pubmed/commentcorrection/19419973-17943122, http://linkedlifedata.com/resource/pubmed/commentcorrection/19419973-17973861, http://linkedlifedata.com/resource/pubmed/commentcorrection/19419973-18193045, http://linkedlifedata.com/resource/pubmed/commentcorrection/19419973-18440328, http://linkedlifedata.com/resource/pubmed/commentcorrection/19419973-18514160, http://linkedlifedata.com/resource/pubmed/commentcorrection/19419973-18668430, http://linkedlifedata.com/resource/pubmed/commentcorrection/19419973-19021734, http://linkedlifedata.com/resource/pubmed/commentcorrection/19419973-3470801, http://linkedlifedata.com/resource/pubmed/commentcorrection/19419973-8467709, http://linkedlifedata.com/resource/pubmed/commentcorrection/19419973-9207286, http://linkedlifedata.com/resource/pubmed/commentcorrection/19419973-9355767, http://linkedlifedata.com/resource/pubmed/commentcorrection/19419973-9375768
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1460-2083
pubmed:author
pubmed:issnType
Electronic
pubmed:day
15
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2711-8
pubmed:dateRevised
2010-9-24
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Common variants in the SLCO1B3 locus are associated with bilirubin levels and unconjugated hyperbilirubinemia.
pubmed:affiliation
Istituto di Neurogenetica e Neurofarmacologia del Consiglio Nazionale delle Ricerche, Monserrato, 09042 Cagliari, Italy.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, N.I.H., Extramural