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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2009-5-15
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pubmed:abstractText |
Ribose-based nucleoside 5'-diphosphates and triphosphates and related nucleotides were compared in their potency at the P2Y receptors with the corresponding nucleoside 5'-phosphonate derivatives. Phosphonate derivatives of UTP and ATP activated the P2Y(2) receptor but were inactive or weakly active at P2Y(4) receptor. Uridine 5'-(diphospho)phosphonate was approximately as potent at the P2Y(2) receptor as at the UDP-activated P2Y(6) receptor. These results suggest that removal of the 5'-oxygen atom from nucleotide agonist derivatives reduces but does not prevent interaction with the P2Y(2) receptor. Uridine 5'-(phospho)phosphonate as well as the 5'-methylenephosphonate equivalent of UMP were inactive at the P2Y(4) receptor and exhibited maximal effects at the P2Y(2) receptor that were 50% of that of UTP suggesting novel action of these analogues.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19419868-11058045,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19419868-11754592,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19419868-16366591,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19419868-16472681,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19419868-16475938,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19419868-16942026,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19419868-16968944,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19419868-17016747,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19419868-17125260,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19419868-17302398,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19419868-18327393,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19419868-18514530,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19419868-18600475,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19419868-2542559,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19419868-8700127
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1464-3405
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3002-5
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:19419868-Adenosine Diphosphate,
pubmed-meshheading:19419868-Adenosine Triphosphate,
pubmed-meshheading:19419868-Cell Line, Tumor,
pubmed-meshheading:19419868-Humans,
pubmed-meshheading:19419868-Nucleotides,
pubmed-meshheading:19419868-Purinergic P2 Receptor Agonists,
pubmed-meshheading:19419868-Receptors, Purinergic P2,
pubmed-meshheading:19419868-Recombinant Proteins,
pubmed-meshheading:19419868-Uridine Diphosphate,
pubmed-meshheading:19419868-Uridine Triphosphate
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pubmed:year |
2009
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pubmed:articleTitle |
Synthesis and P2Y receptor activity of nucleoside 5'-phosphonate derivatives.
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pubmed:affiliation |
Laboratory for Medicinal Chemistry, Faculty of Pharmaceutical Sciences (FFW), Ghent University, Ghent, Belgium.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural,
Research Support, N.I.H., Intramural
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