Linked Life Data

19417508

Source:http://linkedlifedata.com/resource/pubmed/id/19417508

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2009-5-6
pubmed:abstractText
Carbon nanotubes loaded with peptides, proteins and drugs can translocate across the cell membrane. This big advantage has attracted increasing attention to design a novel delivery system using nanotubes. Polyoxometalate (POM) is a promising antitumor drug and it shows a very strong interaction with carbon nanotube surfaces. In this paper, a novel complex of POM-modified single-walled carbon nanotubes (SWNTs) and chitosan was fabricated through a layer-by-layer self-assembly process. With the addition of SWNTs, the loading of POM in this thin film was doubled in the high ionic strength. The initial burst release of POMs in the (POM/chitosan)(n) thin film was suppressed in the (POM-SWNT/chitosan)(n) thin film. Also the instability of POMs in a physiologically relevant pH environment was overcome. The strong interaction between POMs and SWNTs was believed to be the determinant factor in the higher loading and prolonged release of POMs in (POM-SWNT/chitosan)(n) thin films.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1361-6528
pubmed:author
pubmed:issnType
Electronic
pubmed:day
11
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
105101
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Carbon-nanotube-assisted high loading and controlled release of polyoxometalates in biodegradable multilayer thin films.
pubmed:affiliation
Department of Chemistry, Renmin University of China, Beijing 100872, People's Republic of China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't