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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2009-6-1
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pubmed:abstractText |
Optimising islet culture conditions may be one strategy for reducing islet loss prior to, and immediately after, islet transplantation. Liver X receptor (LXR) agonism has previously been shown to increase insulin release from pancreatic islets and reduce inflammation in leucocytes. Our aim was to investigate whether the synthetic LXR agonist GW3965 could modulate the inflammatory status of human pancreatic islets.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Inflammatory Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Benzoic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Benzylamines,
http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers,
http://linkedlifedata.com/resource/pubmed/chemical/CCL2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CCL2,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/GW 3965,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-8,
http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/Methylprednisolone,
http://linkedlifedata.com/resource/pubmed/chemical/Orphan Nuclear Receptors,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cytoplasmic and Nuclear,
http://linkedlifedata.com/resource/pubmed/chemical/Thromboplastin,
http://linkedlifedata.com/resource/pubmed/chemical/liver X receptor
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1432-0428
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
52
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1352-62
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:19415233-Adult,
pubmed-meshheading:19415233-Aged,
pubmed-meshheading:19415233-Anti-Inflammatory Agents,
pubmed-meshheading:19415233-Benzoic Acids,
pubmed-meshheading:19415233-Benzylamines,
pubmed-meshheading:19415233-Biological Markers,
pubmed-meshheading:19415233-Cell Culture Techniques,
pubmed-meshheading:19415233-Cell Survival,
pubmed-meshheading:19415233-Chemokine CCL2,
pubmed-meshheading:19415233-Cholesterol,
pubmed-meshheading:19415233-DNA-Binding Proteins,
pubmed-meshheading:19415233-Female,
pubmed-meshheading:19415233-Gene Expression,
pubmed-meshheading:19415233-Homeostasis,
pubmed-meshheading:19415233-Humans,
pubmed-meshheading:19415233-Insulin,
pubmed-meshheading:19415233-Interleukin-8,
pubmed-meshheading:19415233-Islets of Langerhans,
pubmed-meshheading:19415233-Islets of Langerhans Transplantation,
pubmed-meshheading:19415233-Lipopolysaccharides,
pubmed-meshheading:19415233-Male,
pubmed-meshheading:19415233-Methylprednisolone,
pubmed-meshheading:19415233-Orphan Nuclear Receptors,
pubmed-meshheading:19415233-Receptors, Cytoplasmic and Nuclear,
pubmed-meshheading:19415233-Thromboplastin,
pubmed-meshheading:19415233-Tissue Donors
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pubmed:year |
2009
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pubmed:articleTitle |
The synthetic liver X receptor agonist GW3965 reduces tissue factor production and inflammatory responses in human islets in vitro.
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pubmed:affiliation |
Institute for Surgical Research, Oslo University Hospital, Sognsvannsveien 20, Oslo, Norway. hanne.scholz@medisin.uio.no
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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