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19414330
Source:
http://linkedlifedata.com/resource/pubmed/id/19414330
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Predicate
Object
rdf:type
pubmed:Citation
lifeskim:mentions
umls-concept:C0010762
,
umls-concept:C0018966
,
umls-concept:C0443220
,
umls-concept:C0562558
,
umls-concept:C0678594
,
umls-concept:C1176140
,
umls-concept:C1517880
pubmed:issue
3
pubmed:dateCreated
2009-5-5
pubmed:abstractText
CYP3A4 is the most abundant xenobiotic-metabolizing cytochrome P450 isoform. We examined the structural features of the CYP3A4 molecule with regard to ligand access.
pubmed:language
eng
pubmed:journal
http://linkedlifedata.com/resource/pubmed/journal/8102988
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/CYP3A4 protein, human
,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 CYP3A
,
http://linkedlifedata.com/resource/pubmed/chemical/Erythromycin
,
http://linkedlifedata.com/resource/pubmed/chemical/Heme
,
http://linkedlifedata.com/resource/pubmed/chemical/Ketoconazole
,
http://linkedlifedata.com/resource/pubmed/chemical/Ligands
,
http://linkedlifedata.com/resource/pubmed/chemical/Metyrapone
,
http://linkedlifedata.com/resource/pubmed/chemical/Progesterone
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0250-7005
pubmed:author
pubmed-author:HoriHitoshiH
,
pubmed-author:KawaguchiYukiY
,
pubmed-author:MasubuchiYasuhiroY
,
pubmed-author:OhkuraKazutoK
,
pubmed-author:ShinoharaYasuoY
,
pubmed-author:WatanabeYasukoY
pubmed:issnType
Print
pubmed:volume
29
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
935-42
pubmed:meshHeading
pubmed-meshheading:19414330-Amino Acid Sequence
,
pubmed-meshheading:19414330-Binding Sites
,
pubmed-meshheading:19414330-Crystallography, X-Ray
,
pubmed-meshheading:19414330-Cytochrome P-450 CYP3A
,
pubmed-meshheading:19414330-Erythromycin
,
pubmed-meshheading:19414330-Heme
,
pubmed-meshheading:19414330-Humans
,
pubmed-meshheading:19414330-Ketoconazole
,
pubmed-meshheading:19414330-Ligands
,
pubmed-meshheading:19414330-Metyrapone
,
pubmed-meshheading:19414330-Models, Molecular
,
pubmed-meshheading:19414330-Molecular Sequence Data
,
pubmed-meshheading:19414330-Progesterone
,
pubmed-meshheading:19414330-Protein Binding
,
pubmed-meshheading:19414330-Protein Conformation
,
pubmed-meshheading:19414330-Static Electricity
,
pubmed-meshheading:19414330-Substrate Specificity
pubmed:year
2009
pubmed:articleTitle
Flexible structure of cytochrome P450: promiscuity of ligand binding in the CYP3A4 heme pocket.
pubmed:affiliation
Faculty of Pharmacy, Chiba Institute of Science, Choshi, Chiba, 288-0025, Japan. kohkura@sag.bekkoame.ne.jp
pubmed:publicationType
Journal Article