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pubmed:abstractText |
Major depressive disorder is characterized by impaired reward processing, possibly due to dysfunction in the basal ganglia. However, few neuroimaging studies of depression have distinguished between anticipatory and consummatory phases of reward processing. Using functional MRI (fMRI) and a task that dissociates anticipatory and consummatory phases of reward processing, the authors tested the hypothesis that individuals with major depression would show reduced reward-related responses in basal ganglia structures.
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pubmed:affiliation |
Department of Psychology, Harvard University, 1220 William James Hall, 33 Kirkland St., Cambridge, MA 02138, USA. dap@wjh.harvard.edu
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