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pubmed-article:19410457pubmed:abstractTextSuppression of oncogenic Wnt-mediated signaling holds promise as an anti-cancer therapeutic strategy. We previously reported a novel class of small molecules (IWR-1/2, inhibitors of Wnt response) that antagonize Wnt signaling by stabilizing the Axin destruction complex. Herein, we present the results of structure-activity relationship studies of these compounds.lld:pubmed
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pubmed-article:19410457pubmed:articleTitleStructure-activity relationship studies of small-molecule inhibitors of Wnt response.lld:pubmed
pubmed-article:19410457pubmed:affiliationDepartment of Biochemistry, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA.lld:pubmed
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