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rdf:type |
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|
lifeskim:mentions |
|
|
pubmed:issue |
14
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|
pubmed:dateCreated |
2009-7-13
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|
pubmed:abstractText |
Suppression of oncogenic Wnt-mediated signaling holds promise as an anti-cancer therapeutic strategy. We previously reported a novel class of small molecules (IWR-1/2, inhibitors of Wnt response) that antagonize Wnt signaling by stabilizing the Axin destruction complex. Herein, we present the results of structure-activity relationship studies of these compounds.
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pubmed:grant |
|
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pubmed:commentsCorrections |
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
1464-3405
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pubmed:author |
|
|
pubmed:issnType |
Electronic
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|
pubmed:day |
15
|
|
pubmed:volume |
19
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
3825-7
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|
pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
|
|
pubmed:year |
2009
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|
pubmed:articleTitle |
Structure-activity relationship studies of small-molecule inhibitors of Wnt response.
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|
pubmed:affiliation |
Department of Biochemistry, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA.
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|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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