|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0000726,
umls-concept:C0003483,
umls-concept:C0011306,
umls-concept:C0017262,
umls-concept:C0086418,
umls-concept:C0087111,
umls-concept:C0185117,
umls-concept:C0248813,
umls-concept:C0286651,
umls-concept:C0332257,
umls-concept:C0333348,
umls-concept:C0392756,
umls-concept:C0623362,
umls-concept:C0677535,
umls-concept:C1521761,
umls-concept:C1554080,
umls-concept:C1706198,
umls-concept:C2911684
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2009-10-5
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|
pubmed:abstractText |
Abdominal aortic aneurysm (AAA) accumulates features of a chronic inflammatory disorder and irreversible destruction of connective tissue. A recent experimental study identified c-Jun N terminal kinase (JNK) as a proximal signaling molecule in the pathogenesis of AAA and vascular dendritic cells as key players in the inflammatory reaction and degradation of the extracellular matrix. Statins can inhibit cell proliferation and vascular inflammation, which might help prevent AAA progression. However, supporting clinical data from human studies are lacking. We hypothesized that atorvastatin might inhibit JNK and dendritic cells, resulting in suppression of inflammatory cells and matrix metalloproteinases (MMPs) in human tissue of AAA.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Oct
|
|
pubmed:issn |
1879-1484
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pubmed:author |
|
|
pubmed:issnType |
Electronic
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|
pubmed:volume |
206
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
505-11
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pubmed:meshHeading |
pubmed-meshheading:19406402-Aged,
pubmed-meshheading:19406402-Aged, 80 and over,
pubmed-meshheading:19406402-Aortic Aneurysm, Abdominal,
pubmed-meshheading:19406402-Cell Proliferation,
pubmed-meshheading:19406402-Dendritic Cells,
pubmed-meshheading:19406402-Female,
pubmed-meshheading:19406402-Heptanoic Acids,
pubmed-meshheading:19406402-Humans,
pubmed-meshheading:19406402-Inflammation,
pubmed-meshheading:19406402-JNK Mitogen-Activated Protein Kinases,
pubmed-meshheading:19406402-Male,
pubmed-meshheading:19406402-Matrix Metalloproteinases,
pubmed-meshheading:19406402-Middle Aged,
pubmed-meshheading:19406402-Muscle, Smooth, Vascular,
pubmed-meshheading:19406402-Pyrroles,
pubmed-meshheading:19406402-Tissue Inhibitor of Metalloproteinase-1
|
|
pubmed:year |
2009
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|
pubmed:articleTitle |
Short-term 20-mg atorvastatin therapy reduces key inflammatory factors including c-Jun N-terminal kinase and dendritic cells and matrix metalloproteinase expression in human abdominal aortic aneurysmal wall.
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|
pubmed:affiliation |
Department of Cardiovascular Surgery, Juntendo University, Tokyo, Japan.
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|
pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
|
