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rdf:type |
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lifeskim:mentions |
umls-concept:C0025914,
umls-concept:C0026809,
umls-concept:C0037994,
umls-concept:C0042776,
umls-concept:C0079382,
umls-concept:C0080194,
umls-concept:C0162326,
umls-concept:C0332307,
umls-concept:C0439849,
umls-concept:C0445223,
umls-concept:C0521026,
umls-concept:C1552599,
umls-concept:C1704787
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pubmed:issue |
2
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pubmed:dateCreated |
1977-7-18
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pubmed:abstractText |
The genome of the Friend strain of the spleen focus-forming virus (SFFV) has been analyzed by molecular hybridization. SFFV is composed of genetic sequences homologous to Friend type C helper virus (F-MuLV) and SFFV-specific sequences not present in F-MuLV. These SFFV-specific sequences are present in both the Friend and Rauscher strains of murine erythroleukemia virus. The SFFV-specific sequences are partially homologous to three separate strains of mouse xenotropic virus but not to several cloned mouse ecotropic viruses. Thus, the Friend strain of SFFV appears to be a recombinant between a portion of the F-MuLV genome and RNA sequences that are highly related to murine xenotropic viruses. The implications of the acquisition of the xenotropic virus-related sequences are discussed in relation to the leukemogenicity of SFFV, and a model for the pathogenicity of other murine leukemia-inducing viruses is proposed.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/194058-13416470,
http://linkedlifedata.com/resource/pubmed/commentcorrection/194058-13675761,
http://linkedlifedata.com/resource/pubmed/commentcorrection/194058-14243400,
http://linkedlifedata.com/resource/pubmed/commentcorrection/194058-14490596,
http://linkedlifedata.com/resource/pubmed/commentcorrection/194058-163329,
http://linkedlifedata.com/resource/pubmed/commentcorrection/194058-167514,
http://linkedlifedata.com/resource/pubmed/commentcorrection/194058-169043,
http://linkedlifedata.com/resource/pubmed/commentcorrection/194058-170411,
http://linkedlifedata.com/resource/pubmed/commentcorrection/194058-170737,
http://linkedlifedata.com/resource/pubmed/commentcorrection/194058-172913,
http://linkedlifedata.com/resource/pubmed/commentcorrection/194058-176594,
http://linkedlifedata.com/resource/pubmed/commentcorrection/194058-178890,
http://linkedlifedata.com/resource/pubmed/commentcorrection/194058-183818,
http://linkedlifedata.com/resource/pubmed/commentcorrection/194058-190768,
http://linkedlifedata.com/resource/pubmed/commentcorrection/194058-4099080,
http://linkedlifedata.com/resource/pubmed/commentcorrection/194058-4120907,
http://linkedlifedata.com/resource/pubmed/commentcorrection/194058-4123693,
http://linkedlifedata.com/resource/pubmed/commentcorrection/194058-4127029,
http://linkedlifedata.com/resource/pubmed/commentcorrection/194058-4288557,
http://linkedlifedata.com/resource/pubmed/commentcorrection/194058-4301006,
http://linkedlifedata.com/resource/pubmed/commentcorrection/194058-4311790,
http://linkedlifedata.com/resource/pubmed/commentcorrection/194058-4317349,
http://linkedlifedata.com/resource/pubmed/commentcorrection/194058-4325930,
http://linkedlifedata.com/resource/pubmed/commentcorrection/194058-4332980,
http://linkedlifedata.com/resource/pubmed/commentcorrection/194058-4332982,
http://linkedlifedata.com/resource/pubmed/commentcorrection/194058-4338637,
http://linkedlifedata.com/resource/pubmed/commentcorrection/194058-4357879,
http://linkedlifedata.com/resource/pubmed/commentcorrection/194058-4364897,
http://linkedlifedata.com/resource/pubmed/commentcorrection/194058-4372546,
http://linkedlifedata.com/resource/pubmed/commentcorrection/194058-4505653,
http://linkedlifedata.com/resource/pubmed/commentcorrection/194058-4622766,
http://linkedlifedata.com/resource/pubmed/commentcorrection/194058-4742777,
http://linkedlifedata.com/resource/pubmed/commentcorrection/194058-4831907,
http://linkedlifedata.com/resource/pubmed/commentcorrection/194058-5281193,
http://linkedlifedata.com/resource/pubmed/commentcorrection/194058-62849,
http://linkedlifedata.com/resource/pubmed/commentcorrection/194058-978793
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
361-72
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:194058-Animals,
pubmed-meshheading:194058-Base Sequence,
pubmed-meshheading:194058-Cell Line,
pubmed-meshheading:194058-Clone Cells,
pubmed-meshheading:194058-Friend murine leukemia virus,
pubmed-meshheading:194058-Helper Viruses,
pubmed-meshheading:194058-Leukemia Virus, Murine,
pubmed-meshheading:194058-Mice,
pubmed-meshheading:194058-Molecular Weight,
pubmed-meshheading:194058-Nucleic Acid Conformation,
pubmed-meshheading:194058-Nucleic Acid Hybridization,
pubmed-meshheading:194058-RNA, Viral,
pubmed-meshheading:194058-Rats,
pubmed-meshheading:194058-Recombination, Genetic,
pubmed-meshheading:194058-Retroviridae,
pubmed-meshheading:194058-Virus Replication
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pubmed:year |
1977
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pubmed:articleTitle |
Friend strain of spleen focus-forming virus: a recombinant between mouse type C ecotropic viral sequences and sequences related to xenotropic virus.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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