Source:http://linkedlifedata.com/resource/pubmed/id/19403995
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2009-5-15
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| pubmed:abstractText |
Adult T-cell leukemia (ATL) is a malignant tumor of human CD4(+) T cells infected with a human retrovirus, T lymphotropic virus type-1 (HTLV-1). The aim of the present study was to investigate the apoptotic effects of phenoxazines, 2-amino-4,4alpha-dihydro-4alpha,7-dimethyl-3H-phenoxazine-3-one (Phx-1), 3-amino-1,4alpha-dihydro-4alpha,8-dimethyl-2H-phenoxazine-2-one (Phx-2), and 2-aminophenoxazine-3-one (Phx-3) on a T cell leukemia cell line from ATL patients, MT-1 cells; HTLV-1 transformed T-cell lines, HUT-102 cells and MT-2 cells; and an HTLV-1-negative rat sarcoma cell line, XC cells. Among these phenoxazines, Phx-3 at concentrations of less than 10 microg/ml extensively inhibited growth and cell viability; arrested cell cycles at sub G(0)/G(1) phase; and augmented apoptosis of MT-1, HUT-102, and MT-2 cells. However, these phenoxazines did not affect the cell viability of an HTLV-1-negative rat sarcoma cell line, XC cells, and phytohemaggutinin-activated human peripheral blood mononuclear cells, although they markedly inhibited the growth of these cells. The transmission of HTLV-1 from HTLV-1-positive cells (MT-2 cells) to HTLV-1-negative cells (XC cells) was considered to be prevented by Phx-1, Phx-2, or Phx-3 because the syncytium formation between these cells was inhibited markedly in the presence of these phenoxazines. The present results suggest that Phx-1, Phx-2, and, in particular, Phx-3 may be useful as therapeutic agents against ATL, which is extremely refractory to current therapies.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2-amino-4,4alpha-dihydro-4alpha,7-di...,
http://linkedlifedata.com/resource/pubmed/chemical/3-amino-1,4a-dihydro-4a,8-dimethyl-2...,
http://linkedlifedata.com/resource/pubmed/chemical/3-aminophenoxazone,
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Caspase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Indicators and Reagents,
http://linkedlifedata.com/resource/pubmed/chemical/Oxazines,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/phenoxazine
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| pubmed:status |
MEDLINE
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| pubmed:month |
May
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| pubmed:issn |
1347-8613
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
110
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
87-97
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| pubmed:meshHeading |
pubmed-meshheading:19403995-Animals,
pubmed-meshheading:19403995-Antineoplastic Agents,
pubmed-meshheading:19403995-Apoptosis,
pubmed-meshheading:19403995-Caspase 3,
pubmed-meshheading:19403995-Cell Cycle,
pubmed-meshheading:19403995-Cell Line, Tumor,
pubmed-meshheading:19403995-Cell Proliferation,
pubmed-meshheading:19403995-Cell Survival,
pubmed-meshheading:19403995-Giant Cells,
pubmed-meshheading:19403995-HTLV-I Infections,
pubmed-meshheading:19403995-Human T-lymphotropic virus 1,
pubmed-meshheading:19403995-Humans,
pubmed-meshheading:19403995-Indicators and Reagents,
pubmed-meshheading:19403995-Necrosis,
pubmed-meshheading:19403995-Oxazines,
pubmed-meshheading:19403995-RNA, Neoplasm,
pubmed-meshheading:19403995-Rats,
pubmed-meshheading:19403995-Reverse Transcriptase Polymerase Chain Reaction
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| pubmed:year |
2009
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| pubmed:articleTitle |
Anticancer effects of phenoxazine derivatives revealed by inhibition of cell growth and viability, disregulation of cell cycle, and apoptosis induction in HTLV-1-positive leukemia cells.
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| pubmed:affiliation |
Department of Life and Environmental Sciences, Chiba Institute of Technology, Japan.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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