Linked Life Data

19402638

Source:http://linkedlifedata.com/resource/pubmed/id/19402638

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2009-10-22
pubmed:abstractText
Effects of carbon nanotubes (CNTs) on living systems such as cells are crucial for the safe development of biosensors, drug carriers, or tumor imaging agents. We report here that SWCNT-COOH inhibited cell proliferation via a nonapoptotic mechanism, which is different from effects caused by pristine CNTs. On the basis of SWCNT-COOH's perturbations on cells, expression of genes and protein, and protein phosphorylations, we conclude that SWCNT-COOH suppresses Smad-dependent bone morphogenetic protein (BMP) signaling pathway and down-regulates Id proteins. These molecular events cause cell cycle arrest at G(1)/S transition and inhibit cell proliferation. The specific suppression of BMP signaling and Id proteins by SWCNT-COOH demonstrates nonapoptotic effects of functionalized CNTs on human cells. This finding may have potential therapeutic applications to treat human diseases related to Id proteins or BMP signaling such as breast cancer and bone diseases.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1936-086X
pubmed:author
pubmed:issnType
Electronic
pubmed:day
26
pubmed:volume
3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1139-44
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Suppression of human bone morphogenetic protein signaling by carboxylated single-walled carbon nanotubes.
pubmed:affiliation
St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't