Linked Life Data

19398656

Source:http://linkedlifedata.com/resource/pubmed/id/19398656

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2009-5-21
pubmed:abstractText
We sought to determine whether taurine could specifically protect against coronary artery disease during an atherogenic diet and whether taurine affects the lipid profile, metabolites of methionine, and endothelial atherogenic systems. Rabbits were fed one of the following diets for 4 weeks: (1) control diet; (2) 0.5% cholesterol+1.0% methionine; or (3) 0.5% cholesterol+1.0% methionine+2.5% taurine. Endothelial function was examined, and the left main coronary artery atherosclerosis was quantified by stereology and semiquantitative immunohistochemistry to determine the endothelial expression of proteins related to the NO, renin-angiotensin, endoplasmic reticulum, and oxidative stress systems, as well as apoptosis. Taurine normalized hyperhomocysteinemia (P<0.05) and significantly reduced hypermethioninemia (P<0.05) but not lipidemia. The intima:media ratio was reduced by 28% (P=0.034), and atherosclerosis was reduced by 64% (P=0.012) and endothelial cell apoptosis by 30% (P<0.01). Endothelial cell CCAAT/enhancer binding protein homologous protein was normalized (P<0.05). Taurine failed to improve hyperlipidemia, endothelial function, or endothelial proteins related to the NO, renin-angiotensin, and oxidative stress systems. Taurine reduces left main coronary artery wall pathology associated with decreased plasma total homocysteine, methionine, apoptosis, and normalization of CCAAT/enhancer binding protein homologous protein. These results elucidate the antiapoptotic and antiatherogenic properties of taurine, possibly via normalization of endoplasmic reticulum stress.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1524-4563
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
53
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1017-22
pubmed:meshHeading
pubmed-meshheading:19398656-Analysis of Variance, pubmed-meshheading:19398656-Animals, pubmed-meshheading:19398656-Apoptosis, pubmed-meshheading:19398656-CCAAT-Binding Factor, pubmed-meshheading:19398656-Coronary Artery Disease, pubmed-meshheading:19398656-Diet, Atherogenic, pubmed-meshheading:19398656-Dietary Supplements, pubmed-meshheading:19398656-Disease Models, Animal, pubmed-meshheading:19398656-Endothelium, Vascular, pubmed-meshheading:19398656-Homocysteine, pubmed-meshheading:19398656-Hyperlipidemias, pubmed-meshheading:19398656-Male, pubmed-meshheading:19398656-Methionine, pubmed-meshheading:19398656-Nitric Oxide, pubmed-meshheading:19398656-Oxidative Stress, pubmed-meshheading:19398656-Probability, pubmed-meshheading:19398656-Rabbits, pubmed-meshheading:19398656-Random Allocation, pubmed-meshheading:19398656-Reference Values, pubmed-meshheading:19398656-Sensitivity and Specificity, pubmed-meshheading:19398656-Taurine
pubmed:year
2009
pubmed:articleTitle
High dietary taurine reduces apoptosis and atherosclerosis in the left main coronary artery: association with reduced CCAAT/enhancer binding protein homologous protein and total plasma homocysteine but not lipidemia.
pubmed:affiliation
Departments of Cardiology, University of Melbourne, Austin Health, Heidelberg, Australia. azulli@unimelb.edu.au
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't