Linked Life Data

19396152

Source:http://linkedlifedata.com/resource/pubmed/id/19396152

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2009-6-30
pubmed:abstractText
Increasing evidence indicates that Notch signaling contributes to physiological processes, including development and differentiation, as well as tumorigenesis, either as a tumor promoter or suppressor, depending on cellular context, expression levels and cross talk with other signaling systems. Recent studies reported absent or minimal Notch-1 expression in neuroendocrine tumors of the lung and gastrointestinal tract, suggesting a tumor-suppressor function of Notch-1. Merkel cell carcinoma is a rare and highly aggressive primary cutaneous neuroendocrine carcinoma. Because no information is available on Notch-1 expression in this tumor, we have investigated a series of 31 Merkel cell carcinoma for Notch-1 immunoreactivity. Immunoreactivities for E-cadherin and beta-catenin were also analyzed. All but 1 Merkel cell carcinoma (30 of 31) retained cytoplasmic and membrane Notch-1 expression in more than 50% of cells. beta-Catenin displayed a prevalent membrane-associated staining in 30 of 31 cases, and 22 cases showed more than 50% of immunoreactive cells whereas nuclear beta-catenin was seen only in 2 of 31 cases. E-cadherin membranous expression was remarkably low, as only 1 of 26 cases was found positive in more than 50% of cells. In contrast with neuroendocrine tumors in other tissues, evident Notch-1 expression was found in Merkel cell carcinoma. This finding does not support a tumor-suppressor function of Notch-1 in Merkel cell carcinoma. Downregulation of E-cadherin and diffuse membranous beta-catenin expression suggest a dysregulation of the E-cadherin/beta-catenin complex in Merkel cell carcinoma. This may contribute to local invasion and distant metastasis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1530-0285
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
22
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
959-68
pubmed:meshHeading
pubmed-meshheading:19396152-Adult, pubmed-meshheading:19396152-Aged, pubmed-meshheading:19396152-Aged, 80 and over, pubmed-meshheading:19396152-Cadherins, pubmed-meshheading:19396152-Carcinoid Tumor, pubmed-meshheading:19396152-Carcinoma, Merkel Cell, pubmed-meshheading:19396152-Cell Adhesion, pubmed-meshheading:19396152-Cell Membrane, pubmed-meshheading:19396152-Cytoplasm, pubmed-meshheading:19396152-Down-Regulation, pubmed-meshheading:19396152-Female, pubmed-meshheading:19396152-Fluorescent Antibody Technique, Indirect, pubmed-meshheading:19396152-Humans, pubmed-meshheading:19396152-Immunoenzyme Techniques, pubmed-meshheading:19396152-Male, pubmed-meshheading:19396152-Middle Aged, pubmed-meshheading:19396152-Receptor, Notch1, pubmed-meshheading:19396152-Skin Neoplasms, pubmed-meshheading:19396152-Survival Rate, pubmed-meshheading:19396152-Tumor Markers, Biological, pubmed-meshheading:19396152-beta Catenin
pubmed:year
2009
pubmed:articleTitle
Expression of Notch-1 and alteration of the E-cadherin/beta-catenin cell adhesion complex are observed in primary cutaneous neuroendocrine carcinoma (Merkel cell carcinoma).
pubmed:affiliation
Department of Human Pathology and Oncology, University of Florence, Florence, Italy.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't