Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
22
pubmed:dateCreated
2009-6-2
pubmed:abstractText
Purified histone H2A.Z from chicken erythrocytes and a sodium butyrate-treated chicken erythroleukemic cell line was used as a model system to identify the acetylation sites (K4, K7, K11, K13, and K15) and quantify their distribution in this vertebrate histone variant. To understand the role played by acetylation in the modulation of the H2A.Z nucleosome core particle (NCP) stability and conformation, an extensive analysis was conducted on NCPs reconstituted from acetylated forms of histones, including H2A.Z and recombinant H2A.Z (K/Q) acetylation mimic mutants. Although the overall global acetylation of core histones destabilizes the NCP, we found that H2A.Z stabilizes the NCP regardless of its state of acetylation. Interestingly and quite unexpectedly, we found that the change in NCP conformation induced by global histone acetylation is dependent on H2A/H2A.Z acetylation. This suggests that acetylated H2A variants act synergistically with the acetylated forms of the core histone complement to alter the particle conformation. Furthermore, the simultaneous occurrence of H2A.Z and H2A in heteromorphic NCPs that most likely occurs in vivo slightly destabilizes the NCP, but only in the presence of acetylation.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/19385636-10022893, http://linkedlifedata.com/resource/pubmed/commentcorrection/19385636-10801889, http://linkedlifedata.com/resource/pubmed/commentcorrection/19385636-10938086, http://linkedlifedata.com/resource/pubmed/commentcorrection/19385636-11008759, http://linkedlifedata.com/resource/pubmed/commentcorrection/19385636-11101893, http://linkedlifedata.com/resource/pubmed/commentcorrection/19385636-11430834, http://linkedlifedata.com/resource/pubmed/commentcorrection/19385636-11550192, http://linkedlifedata.com/resource/pubmed/commentcorrection/19385636-11551971, http://linkedlifedata.com/resource/pubmed/commentcorrection/19385636-12628191, http://linkedlifedata.com/resource/pubmed/commentcorrection/19385636-12665578, http://linkedlifedata.com/resource/pubmed/commentcorrection/19385636-14718166, http://linkedlifedata.com/resource/pubmed/commentcorrection/19385636-15452126, http://linkedlifedata.com/resource/pubmed/commentcorrection/19385636-15663933, http://linkedlifedata.com/resource/pubmed/commentcorrection/19385636-16117653, http://linkedlifedata.com/resource/pubmed/commentcorrection/19385636-16204459, http://linkedlifedata.com/resource/pubmed/commentcorrection/19385636-16239142, http://linkedlifedata.com/resource/pubmed/commentcorrection/19385636-16319397, http://linkedlifedata.com/resource/pubmed/commentcorrection/19385636-16543219, http://linkedlifedata.com/resource/pubmed/commentcorrection/19385636-16543222, http://linkedlifedata.com/resource/pubmed/commentcorrection/19385636-16543223, http://linkedlifedata.com/resource/pubmed/commentcorrection/19385636-16627869, http://linkedlifedata.com/resource/pubmed/commentcorrection/19385636-16707487, http://linkedlifedata.com/resource/pubmed/commentcorrection/19385636-16809769, http://linkedlifedata.com/resource/pubmed/commentcorrection/19385636-16914441, http://linkedlifedata.com/resource/pubmed/commentcorrection/19385636-17392789, http://linkedlifedata.com/resource/pubmed/commentcorrection/19385636-17444617, http://linkedlifedata.com/resource/pubmed/commentcorrection/19385636-17445770, http://linkedlifedata.com/resource/pubmed/commentcorrection/19385636-17446892, http://linkedlifedata.com/resource/pubmed/commentcorrection/19385636-17512414, http://linkedlifedata.com/resource/pubmed/commentcorrection/19385636-17567991, http://linkedlifedata.com/resource/pubmed/commentcorrection/19385636-17575054, http://linkedlifedata.com/resource/pubmed/commentcorrection/19385636-17644761, http://linkedlifedata.com/resource/pubmed/commentcorrection/19385636-17671089, http://linkedlifedata.com/resource/pubmed/commentcorrection/19385636-17938198, http://linkedlifedata.com/resource/pubmed/commentcorrection/19385636-18268003, http://linkedlifedata.com/resource/pubmed/commentcorrection/19385636-18275809, http://linkedlifedata.com/resource/pubmed/commentcorrection/19385636-18316479, http://linkedlifedata.com/resource/pubmed/commentcorrection/19385636-18654629, http://linkedlifedata.com/resource/pubmed/commentcorrection/19385636-18950220, http://linkedlifedata.com/resource/pubmed/commentcorrection/19385636-19088306, http://linkedlifedata.com/resource/pubmed/commentcorrection/19385636-2339060, http://linkedlifedata.com/resource/pubmed/commentcorrection/19385636-2541913, http://linkedlifedata.com/resource/pubmed/commentcorrection/19385636-2716057, http://linkedlifedata.com/resource/pubmed/commentcorrection/19385636-276864, http://linkedlifedata.com/resource/pubmed/commentcorrection/19385636-3012532, http://linkedlifedata.com/resource/pubmed/commentcorrection/19385636-3132988, http://linkedlifedata.com/resource/pubmed/commentcorrection/19385636-3964683, http://linkedlifedata.com/resource/pubmed/commentcorrection/19385636-6429143, http://linkedlifedata.com/resource/pubmed/commentcorrection/19385636-657272, http://linkedlifedata.com/resource/pubmed/commentcorrection/19385636-7217105, http://linkedlifedata.com/resource/pubmed/commentcorrection/19385636-7629098, http://linkedlifedata.com/resource/pubmed/commentcorrection/19385636-8114086, http://linkedlifedata.com/resource/pubmed/commentcorrection/19385636-9024683, http://linkedlifedata.com/resource/pubmed/commentcorrection/19385636-9740721, http://linkedlifedata.com/resource/pubmed/commentcorrection/19385636-9804968
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1520-4995
pubmed:author
pubmed:issnType
Electronic
pubmed:day
9
pubmed:volume
48
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5007-17
pubmed:dateRevised
2011-8-1
pubmed:meshHeading
More...